Cuproptosis-related gene subtypes predict prognosis in patients with head and neck squamous cell carcinoma

Journal of Otolaryngology - Head & Neck Surgery

Original Research Article

Chi Wang¹  Yu Zhou² 

[1] Department of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China;Department of Orthodontics, School & Hospital of Stomatology, Wenzhou Medical University, 373 West College Road, 325000, Wenzhou, Zhejiang, China;

关键词: Head and neck squamous cell carcinoma;    Cuproptosis;    Genes;    Prognosis;    Survival model;   

DOI  :  10.1186/s40463-023-00655-4

 received in 2022-12-30, accepted in 2023-07-23,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundHead and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. A novel form of copper-dependent and reactive oxygen species (ROS)-dependent cell death, cuproptosis, has been described in many cancers. The roles and potential mechanisms of cuproptosis-related genes (CRGs) are still unclear in HNSCC.MethodWe downloaded TCGA datasets of HNSCC genomic mutations and clinic data from The Cancer Genome Atlas. Based on the Cuproptosis-related differentially expressed genes in HNSCC, we constructed a prognostic signature.ResultsEight CRGs have been identified as associated with the prognosis of HNSCC. According to Kaplan–Meier analyses, HNSCC with a high Risk Score had a poor prognosis. Furthermore, the AUC of the Risk Score for the 1-, 3-, and 5- year overall survival was respectively, 0.70, 0.71, and 0.68. TCGA data revealed that T cell functions, such as HLA, cytolytic activity, inflammation regulation, co-inhibition, and co-stimulation, differed significantly between members of the low and high groups. The immune checkpoint genes PD-L1, PD-L1, and CTLA-4 were also expressed differently in the two risk groups.ConclusionsA CRG signature was defined that is associated with the prognosis of patients with HNSCC.Graphical abstract

【 授权许可】

CC BY   
© Canadian Society Of Otolaryngology-Head & Neck Surgery 2023

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