Effects of lifestyle physical activity and sedentary behaviour interventions on disease activity and patient- and clinician- important health outcomes in rheumatoid arthritis: a systematic review with meta-analysis

BMC Rheumatology

Research

George S. Metsios¹  Petros C. Dinas²  Saleh M. A. Elmsmari³  Tom E. Nightingale⁴  Joan L. Duda⁵  George D. Kitas⁶  Sophia M. Brady⁷  Jet J. C. S. Veldhuijzen van Zanten⁷  Sally A. M. Fenton⁷ 

[1] Department of Nutrition and Dietetics, School of Physical Education, Sport Science and Dietetics, University of Thessaly, Thessaly, Greece;FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, Thessaly, Greece;School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, B15 2TT, Birmingham, UK;School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, B15 2TT, Birmingham, UK;Centre for Trauma Science Research, University of Birmingham, Birmingham, UK;School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, B15 2TT, Birmingham, UK;Institute of Mental Health, University of Birmingham, Birmingham, UK;School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, B15 2TT, Birmingham, UK;Rheumatology Department, Dudley Group NHS Foundation Trust, Dudley, UK;School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, B15 2TT, Birmingham, UK;Rheumatology Department, Dudley Group NHS Foundation Trust, Dudley, UK;Medical Research Council- Versus Arthritis Centre for Musculoskeletal Ageing, University of Birmingham, Birmingham, UK;

关键词: Rheumatoid arthritis;    Systematic review;    Physical activity;    Sedentary behaviour;    Intervention;    Lifestyle physical activity;    Health;    Disease activity;   

DOI  :  10.1186/s41927-023-00352-9

 received in 2023-01-09, accepted in 2023-08-23,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundLifestyle physical activity (PA) is defined as any type of PA undertaken as part of daily life. It can include engagement in activities of daily living (i.e., household chores, gardening, walking to work), incidental PA, walking and/or reducing sedentary or sitting behaviours (SB). Regular PA is recommended for people with Rheumatoid Arthritis (RA) to reduce disease activity and systemic inflammation, as well as to improve patient- and clinician-important health outcomes. However, there is no summarised evidence of the effectiveness of interventions specifically targeting lifestyle PA and SB in this population. The aims of this systematic review with meta-analysis were to evaluate interventions targeting lifestyle PA and/or SB on 1) disease activity; 2) PA, SB and 3) patient- and clinician-important outcomes in people with RA.MethodsEight databases [Medline, Cochrane Library CENTRAL, Web of Science, PsychINFO, Cumulative Index to Nursing & Allied Health Literature, Scopus, Excerpta Medica database and Physiotherapy Evidence Database] were searched from inception-August 2022. Inclusion criteria required interventions to target lifestyle PA and/or SB, conducted in adults with RA, assessing patient- and/or clinician-important outcomes.ResultsOf 880 relevant articles, 16 interventions met the inclusion criteria. Meta-analyses showed statistically significant effects of interventions on disease activity (standardised mean difference = -0.12 (95% confidence interval = -0.23 to -0.01, I2 = 6%, z = 2.19, p = .03), moderate-to-vigorous PA, light/leisure PA, steps, functional ability, and fatigue. Whereas, no intervention effects were visualised for total PA, pain, anxiety or quality of life.ConclusionsLifestyle PA interventions led to increased PA, reductions in SB and improvements in disease activity and other patient- and/or clinician-important health outcomes in people with RA. Future interventions should be less heterogenous in content, structure, focus and outcome measures used to aid understanding of the most effective intervention components for improving health. More SB interventions are needed to determine their effectiveness at producing clinical benefits.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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