Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity

Frontiers in Immunology

Immunology

Xiaomin Su¹  Rongcun Yang¹  Yunhuan Gao¹ 

[1] Translational Medicine Institute, Affiliated Tianjin Union Medical Center of Nankai University, Nankai University, Tianjin, China;State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China;Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China;

关键词: gut microbiota;    bile acids;    deoxycholic acid;    lithocholic acid;    tolerogenic macrophages;    regulatory B cells;    regulatory T cells;   

DOI  :  10.3389/fimmu.2023.1127743

 received in 2022-12-19, accepted in 2023-03-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

Bile acids (BAs) as cholesterol-derived molecules play an essential role in some physiological processes such as nutrient absorption, glucose homeostasis and regulation of energy expenditure. They are synthesized in the liver as primary BAs such as cholic acid (CA), chenodeoxycholic acid (CDCA) and conjugated forms. A variety of secondary BAs such as deoxycholic acid (DCA) and lithocholic acid (LCA) and their derivatives is synthesized in the intestine through the involvement of various microorganisms. In addition to essential physiological functions, BAs and their metabolites are also involved in the differentiation and functions of innate and adaptive immune cells such as macrophages (Macs), dendritic cells (DCs), myeloid derived suppressive cells (MDSCs), regulatory T cells (Treg), Breg cells, T helper (Th)17 cells, CD4 Th1 and Th2 cells, CD8 cells, B cells and NKT cells. Dysregulation of the BAs and their metabolites also affects development of some diseases such as inflammatory bowel diseases. We here summarize recent advances in how BAs and their metabolites maintain gut and systemic homeostasis, including the metabolism of the BAs and their derivatives, the role of BAs and their metabolites in the differentiation and function of immune cells, and the effects of BAs and their metabolites on immune-associated disorders.

【 授权许可】

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Copyright © 2023 Su, Gao and Yang