Synthesis of New Cisplatin Derivatives from Bile Acids

Molecules

Agnieszka Hryniewicka¹  Aneta M. Tomkiel¹  Zenon Łotowski¹  Barbara Seroka¹  Jacek W. Morzycki¹  Rafal R. Sicinski²  Lucie Rárová³ 

[1] Faculty of Chemistry, University of Białystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland;Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland;Laboratory of Growth Regulators, Faculty of Science, Palacký University, and Institute of Experimental Botany of the Czech Academy of Sciences, Šlechtitelů 27, CZ-78371 Olomouc, Czech Republic;

关键词: bile acids;    lithocholic acid;    deoxycholic acid;    hyodeoxycholic acid;    cholic acid;    steroidal diamines;    platinum(ii) complexes;   

DOI  :  10.3390/molecules25030655

来源: DOAJ

【 摘 要 】

A series of bile acid derived 1,2- and 1,3-diamines as well as their platinum(II) complexes were designed and synthesized in hope to get a highly cytotoxic compound by the combination of two bioactive moieties. All complexes obtained were subjected to cytotoxicity assays in vitro and some hybrid molecules showed an expected activity.

【 授权许可】

Unknown