ED visits, hospital admissions and treatment breaks in head/neck cancer patients undergoing radiotherapy

Frontiers in Oncology

Oncology

Melissa Masforroll¹  Zoukaa B. Sargi²  Maria A. Rueda-Lara³  Deukwoo Kwon⁴  Michael A. Samuels⁵  Laura M. Freedman⁵  Ruben Carmona⁵  Matthew C. Abramowitz⁵  Gregory A. Azzam⁵  Benjamin J. Rich⁵  Cyrus Washington⁵  Leif-Erik D. Schumacher⁵  Shareen Patel⁵  Stuart E. Samuels⁵ 

[1]Department of Medicine, Florida International University, Miami, FL, United States

[2]Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United States

[3]Department of Psychiatry, University of Miami Miller School of Medicine, Miami, FL, United States

[4]Department of Public Health Sciences, Biostatistics and Bioinformatics Shared Resource, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States

[5]Department of Radiation Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States

关键词: head/neck cancer;    radiation therapy;    hospital admissions;    ED visits;    treatment breaks;    head and neck neoplasms;    radiotherapy;    hospital admissions;   

DOI  :  10.3389/fonc.2023.1147474

 received in 2023-01-18, accepted in 2023-02-08,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectivesRadiation therapy (RT) is an integral part of treatment of head/neck cancer (HNC) but is associated with many toxicities. We sought to evaluate sociodemographic, pathologic, and clinical factors associated with emergency department (ED) visits, hospital admissions (HA), and RT breaks in HNC patients undergoing curative-intent RT.MethodsWe completed a Level 3 (Oxford criteria for evidence-based medicine) analysis of a cohort of HNC patients who underwent curative-intent RT at our institution from 2013 to 2017. We collected demographic characteristics and retrospectively assessed for heavy opioid use, ED visits or HA during RT as well as RT breaks. Treatment breaks were defined as total days to RT fractions ratio ≥1.6. Multivariable stepwise logistic regression analyses were done to determine the association of various sociodemographic, pathologic, and clinical characteristics with ED visits, HA and RT treatment breaks.ResultsThe cohort included 376 HNC patients (294 male, 82 female, median age 61). On multivariable analysis, significant factors associated with ED visits during RT were heavy opioid use and black race. Receipt of concomitant chemotherapy was the only factor associated with hospital admissions during RT. Advanced age, lower socioeconomic class, glandular site, and receipt of chemotherapy were all independently associated with RT breaks. Lower cancer stage and lack of substance abuse history were independently associated with lack of treatment breaks.ConclusionHNC patients with factors such as heavy opioid use, Black race, receipt of concomitant chemotherapy, and lower socioeconomic class may require closer monitoring during RT.

【 授权许可】

Unknown   
Copyright © 2023 Patel, Rich, Schumacher, Sargi, Masforroll, Washington, Kwon, Rueda-Lara, Freedman, Samuels, Abramowitz, Samuels, Carmona and Azzam