Physical activity is related to disease severity and fatigue, but not to relapse rate in persons with relapsing remitting multiple sclerosis – a self-reported questionnaire based study

Frontiers in Neurology

Neurology

Sven T. Hübner¹  Annette Rademacher²  Florian Wolf³  Clemens Warnke⁴  Jens Bansi⁵  David Walzik⁶  Marit L. Schlagheck⁶  Niklas Joisten⁶  Philipp Zimmer⁶ 

[1] Department for Molecular and Cellular Sports Medicine, Institute for Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany;Department for Molecular and Cellular Sports Medicine, Institute for Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany;Marianne-Strauß-Klinik, Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke gGmbH, Berg, Germany;Department for Molecular and Cellular Sports Medicine, Institute for Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany;Neurological Rehabilitation Centre Godeshöhe, Bonn, Germany;Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany;Department of Research and Development, Kliniken Valens, Valens, Switzerland;Department of Health, OST – Eastern Swiss University of Applied Sciences, St. Gallen, Switzerland;Division of Performance and Health, Institute for Sport and Sport Science, Technical University Dortmund, Dortmund, Germany;

关键词: multiple sclerosis;    physical activity;    disease severity;    fatigue;    relapsing remitting multiple sclerosis;   

DOI  :  10.3389/fneur.2023.1217000

 received in 2023-05-04, accepted in 2023-07-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionBased on theoretical models, physical activity has been introduced as a promoting method to mitigate the disease severity, fatigue and relapse rate in multiple sclerosis. The primary objective of the study was to investigate the relation between self-reported physical activity level and disease severity, fatigue and relapse rate in persons with relapsing remitting multiple sclerosis (RRMS).MethodsA survey was offered to persons with RRMS from March 2019 to August 2021 (n = 253). Physical activity level, fatigue and disease severity were determined using the Godin Leisure-Time Questionnaire (GLTEQ), the Patient Determined Disease Steps (PDDS) scale and the Fatigue Scale for Motor and Cognitive Functions (FSMC). Additionally, participants’ relapse rate was recorded.ResultsBivariate correlations revealed an inverse relation between physical activity level and PDDS (ρ = −0.279; p < 0.001) as well as between physical activity and FSMC (r = −0.213, p < 0.001), but not between physical activity and relapse rate (r = 0.033, p > 0.05). Multiple linear regression analyses explained 12.6% and 5.2% of the variance of PDDS and FSMC.ConclusionOur findings confirm a relation between self-reported physical activity, disease severity and fatigue in persons with RRMS. However, self-reported physical activity level does not seem to affect the annualised relapse rate.

【 授权许可】

Unknown   
Copyright © 2023 Schlagheck, Hübner, Joisten, Walzik, Rademacher, Wolf, Bansi, Warnke and Zimmer.