Mechanisms of action and synergetic formulas of plant-based natural compounds from traditional Chinese medicine for managing osteoporosis: a literature review

Frontiers in Medicine

Medicine

Huan Luo¹  Lingfeng Zeng²  Yuliang Zhang³  Muxin Zhang⁴  Hongfeng Ruan⁴  Shuchao Shen⁴  Chengliang Wu⁴  Chengcong Zhou⁴ 

[1] Department of Pharmacy, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China;Hangzhou Fuyang Hospital of TCM Orthopedics and Traumatology, Hangzhou, China;Institute of Orthopaedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China;

关键词: osteoporosis;    traditional Chinese medicine herbs;    plant-based natural products;    bone homeostasis;    active ingredients;    anti-osteoporosis drug;   

DOI  :  10.3389/fmed.2023.1235081

 received in 2023-06-05, accepted in 2023-08-15,  发布年份 2023

来源: Frontiers

【 摘 要 】

Osteoporosis (OP) is a systemic skeletal disease prevalent in older adults, characterized by substantial bone loss and deterioration of microstructure, resulting in heightened bone fragility and risk of fracture. Traditional Chinese Medicine (TCM) herbs have been widely employed in OP treatment owing to their advantages, such as good tolerance, low toxicity, high efficiency, and minimal adverse reactions. Increasing evidence also reveals that many plant-based compounds (or secondary metabolites) from these TCM formulas, such as resveratrol, naringin, and ginsenoside, have demonstrated beneficial effects in reducing the risk of OP. Nonetheless, the comprehensive roles of these natural products in OP have not been thoroughly clarified, impeding the development of synergistic formulas for optimal OP treatment. In this review, we sum up the pathological mechanisms of OP based on evidence from basic and clinical research; emphasis is placed on the in vitro and preclinical in vivo evidence-based anti-OP mechanisms of TCM formulas and their chemically active plant constituents, especially their effects on imbalanced bone homeostasis regulated by osteoblasts (responsible for bone formation), osteoclasts (responsible for bone resorption), bone marrow mesenchymal stem cells as well as bone microstructure, angiogenesis, and immune system. Furthermore, we prospectively discuss the combinatory ingredients from natural products from these TCM formulas. Our goal is to improve comprehension of the pharmacological mechanisms of TCM formulas and their chemically active constituents, which could inform the development of new strategies for managing OP.

【 授权许可】

Unknown   
Copyright © 2023 Zhou, Shen, Zhang, Luo, Zhang, Wu, Zeng and Ruan.