Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts

Frontiers in Endocrinology

Endocrinology

Yixin Deng¹  Yonghong Huang²  Jinhui Lao³  Yaqun Wang³  Hong Xu³  Hangxiu Che⁴  Chirui Xu⁵  Hanxiao Yin⁵  Zheng Tang⁶ 

[1] Basic Medicine, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, China;Department of Pathophysiology, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, China;Department of Physiology, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, China;Department of Physiology, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, China;Joint Program of Nanchang University and Queen Mary University of London, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, China;Huankui Academy, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, China;The Second Clinical Medicine, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, China;

关键词: obesity;    purinergic signalling;    ATP;    P1 receptor;    P2 receptor;   

DOI  :  10.3389/fendo.2023.1181948

 received in 2023-03-08, accepted in 2023-06-15,  发布年份 2023

来源: Frontiers

【 摘 要 】

Obesity has become one of the major public health problems in both the developing and developed countries. Recent studies have suggested that the purinergic signalling is involved in obesity-associated end-organ damage through purine P1 and P2 receptors. In the search for new components for the treatments of obesity, we and other researchers have found much evidence that natural plant extracts may be promising novel therapeutic approaches by modulating purinergic signalling. In this review, we summarize a critical role of purinergic signalling in modulating obesity-associated end-organ damage, such as overhigh appetite, myocardial ischemia, inflammation, atherosclerosis, non-alcoholic fatty liver disease (NAFLD), hepatic steatosis and renal inflammation. Moreover, we focus on the potential roles of several natural plant extracts, including quercetin, resveratrol/trans-resveratrol, caffeine, evodiamine and puerarin, in alleviating obesity-associated end-organ damage via purinergic signalling. We hope that the current knowledge of the potential roles of natural plant extracts in regulating purinergic signalling would provide new ideas for the treatment of obesity and obesity-associated end-organ damage.

【 授权许可】

Unknown   
Copyright © 2023 Che, Wang, Lao, Deng, Xu, Yin, Tang, Huang and Xu