Association between weight-adjusted-waist index with hepatic steatosis and liver fibrosis: a nationally representative cross-sectional study from NHANES 2017 to 2020

Frontiers in Endocrinology

Endocrinology

Kai Zhu¹  Minghan Fu¹  Yahui Wu¹  Yun Shen¹  Jinsheng Wang² 

[1] Department of Pathology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China;Department of Pathology, Changzhi Medical College the First Clinical College, Changzhi, Shanxi, China;Department of Pathology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China;Department of Pathology, Changzhi Medical College the First Clinical College, Changzhi, Shanxi, China;Key Laboratory of Esophageal Cancer Basic Research and Clinical Transformation, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China;

关键词: WWI;    steatosis;    and fibrosis weight-adjusted-waist index;    hepatic steatosis;    liver fibrosis;    NAFLD;    NHANES;    VCTE;   

DOI  :  10.3389/fendo.2023.1159055

 received in 2023-02-05, accepted in 2023-05-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe negative effects of obesity on hepatic steatosis and fibrosis have received considerable attention in recent years. The weight-adjusted-waist index (WWI) reflects weight-independent centripetal obesity. Herein, we provide the first investigation of a link between WWI, hepatic steatosis, and liver fibrosis.MethodsWe used data from the National Health and Nutrition Examination Survey 2017-2020 to conduct a cross-sectional study. The linear relationship between WWI, controlled attenuation parameters, and liver stiffness measurements (LSM) was investigated using multivariate linear regression models. The nonlinear relationship was described using fitted smoothed curves and threshold effect analyses. Subgroup analyses were performed based on gender, age, body mass index, diabetes, hypertension, drinking, and smoking.ResultsThis population-based study included 7,594 people, 50.74% of whom were men and 49.26% of whom were women. Multivariate linear regression analysis revealed a significant positive relationship between WWI and hepatic steatosis [CAP, β=7.60, 95% confidence interval (CI) (4.42, 10.78), P<0.0001]. This positive association was stronger when excessive alcohol intake was present compared to when it was absent (P for interaction = 0.031), and when hypertension was present compared to when it was not (P for interaction = 0.014). The linear relationship between WWI and liver fibrosis was not statistically significant on multiple regression analysis [LSM, β=0.03, 95% CI (-0.26, 0.32), P=0.84]. However, a U-shaped association was seen between WWI and LSM, with a negative correlation when WWI< 10.92 and a positive correlation when WWI > 10.92.ConclusionWe report a strong association between WWI and hepatic steatosis, and suggest that it may potentially be used as a simple anthropometric index to predict hepatic steatosis.

【 授权许可】

Unknown   
Copyright © 2023 Shen, Wu, Fu, Zhu and Wang