Alterations of the gut microbiota associated with the occurrence and progression of viral hepatitis

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Ping Cui¹  Jie Zhou²  Xing Yang²  Liuyan Lan²  Baodong Guo²  Fang Lu²  Zhuoxin Li²  Xiping Yang²  Qing Wang²  Li Ye²  Huanzhuo Mai²  Jiegang Huang³  Hao Liang⁴ 

[1] Guangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, China;Life Science Institute, Guangxi Medical University, Nanning, China;Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning, China;School of Public Health, Guangxi Medical University, Nanning, China;Guangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, China;School of Public Health, Guangxi Medical University, Nanning, China;Guangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, China;Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China;School of Public Health, Guangxi Medical University, Nanning, China;Guangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, China;Life Science Institute, Guangxi Medical University, Nanning, China;Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning, China;

关键词: gut microbiota;    16s ribosomal RNA gene amplicon sequencing;    viral hepatitis;    liver disease;    microbial markers;   

DOI  :  10.3389/fcimb.2023.1119875

 received in 2022-12-09, accepted in 2023-05-22,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundGut microbiota is the largest population of microorganisms and is closely related to health. Many studies have explored changes in gut microbiota in viral hepatitis. However, the correlation between gut microbiota and the occurrence and progression of viral hepatitis has not been fully clarified.MethodsPubMed and BioProject databases were searched for studies about viral hepatitis disease and 16S rRNA gene sequencing of gut microbiota up to January 2023. With bioinformatics analyses, we explored changes in microbial diversity of viral hepatitis, screened out crucial bacteria and microbial functions related to viral hepatitis, and identified the potential microbial markers for predicting risks for the occurrence and progression of viral hepatitis based on ROC analysis.ResultsOf the 1389 records identified, 13 studies met the inclusion criteria, with 950 individuals including 656 patient samples (HBV, n = 546; HCV, n = 86; HEV, n = 24) and 294 healthy controls. Gut microbial diversity is significantly decreased as the infection and progression of viral hepatitis. Alpha diversity and microbiota including Butyricimonas, Escherichia-Shigella, Lactobacillus, and Veillonella were identified as the potential microbial markers for predicting the risk of development of viral hepatitis (AUC>0.7). Microbial functions including tryptophan metabolism, fatty acid biosynthesis, lipopolysaccharide biosynthesis, and lipid metabolism related to the microbial community increased significantly as the development of viral hepatitis.ConclusionsThis study demonstrated comprehensively the gut microbiota characteristics in viral hepatitis, screened out crucial microbial functions related to viral hepatitis, and identified the potential microbial markers for predicting the risk of viral hepatitis.

【 授权许可】

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Copyright © 2023 Yang, Mai, Zhou, Li, Wang, Lan, Lu, Yang, Guo, Ye, Cui, Liang and Huang