Berberine influences multiple diseases by modifying gut microbiota

Frontiers in Nutrition

Nutrition

Rongmao Gao¹  Xiaoxiu Luo¹  Rongan Liu¹  Daqian Xiong²  Fujie Yang³ 

[1] Department of ICU, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China;Department of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China;Department of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China;College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, China;

关键词: berberine;    gut microbiota;    metabolic diseases;    liver disease;    intestinal diseases;    autoimmune diseases;   

DOI  :  10.3389/fnut.2023.1187718

 received in 2023-03-24, accepted in 2023-07-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

Berberine (BBR) is an isoquinoline alkaloid that is widely distributed in the plant kingdom and is commonly found in Coptis chinensis Franch. It has low bioavailability, but it can interact with gut microbiota and affect a variety of diseases. The effects of BBR in diabetes, hyperlipidemia, atherosclerosis, liver diseases, intestinal diseases, mental disorders, autoimmune diseases, and other diseases are all thought to be related to gut microbiota. This review systematically and comprehensively summarize these interactions and their effects, and describes the changes of gut microbiota after the intervention of different doses of berberine and its potential clinical consequences, in order to provide a basis for the rational application of BBR in the future clinical treatment.

【 授权许可】

Unknown   
Copyright © 2023 Yang, Gao, Luo, Liu and Xiong.