期刊论文详细信息
Frontiers in Physiology | |
Pocket ACEs: Discovering new function within an old player | |
Physiology | |
Matthew Leong1  Manita Chaum1  Xiaomo Li2  | |
[1]Cedars Sinai Medical Center, Los Angeles, CA, United States | |
[2]null | |
关键词: ACE; macrophage; hemato- and immunological effects; neutrophil; anti inflammation; immunmodulation; RAS; | |
DOI : 10.3389/fphys.2023.1151908 | |
received in 2023-01-26, accepted in 2023-02-27, 发布年份 2023 | |
来源: Frontiers | |
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【 摘 要 】
Angiotensin-converting enzyme (ACE) is canonically known for its role in the renin-angiotensin system (RAS) where its conversion of angiotensin I (Ang I) to the bioactive peptide angiotensin II (Ang II) helps to regulate blood pressure, electrolyte, and volume homeostasis. Further studies on ACE have shown that its enzymatic activity is relatively non-specific and functions outside of the RAS axis. Of the multiple systems it has been implicated in, ACE has been found to play an important role in the development and modulation of hematopoiesis and the immune system, both through the RAS and independently of the RAS axis.【 授权许可】
Unknown
Copyright © 2023 Leong, Li and Chaum.
【 预 览 】
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RO202310109451892ZK.pdf | 835KB | ![]() |