Multi-functional adaptor SKAP1: regulator of integrin activation, the stop-signal, and the proliferation of T cells

Frontiers in Immunology

Immunology

Monika Raab¹  Yirui Gui²  Chen Liu²  Christopher E. Rudd³ 

[1] Department of Obstetrics and Gynaecology, School of Medicine, J.W. Goethe-University, Frankfurt, Germany;Faculté de Medicine, Université de Montréal, Montréal, QC, Canada;Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC, Canada;Division of Immunology-Oncology, Centre de Recherche de l’Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada;Faculté de Medicine, Université de Montréal, Montréal, QC, Canada;Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC, Canada;Division of Immunology-Oncology, Centre de Recherche de l’Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada;Division of Experimental Medicine, McGill University, Montreal, QC, Canada;

关键词: T-cells;    signalling;    adaptor protein;    integrin activation;    SKAP1;   

DOI  :  10.3389/fimmu.2023.1192838

 received in 2023-03-24, accepted in 2023-05-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

T-cell activation is a complex process involving a network of kinases and downstream molecular scaffolds or adaptors that integrate surface signals with effector functions. One key immune-specific adaptor is Src kinase-associated phosphoprotein 1 (SKAP1), which is also known as src kinase-associated protein of 55 kDa (SKAP55). This mini-review explains how SKAP1 plays multiple roles in regulating integrin activation, the “stop-signal”, and the optimization of the cell cycling of proliferating T cells through interactions with various mediators, including the Polo-like kinase 1 (PLK1). Ongoing research on SKAP1 and its binding partners will likely provide important insights into the regulation of immune function and have implications for the development of new treatments for disease states such as cancer and autoimmunity.

【 授权许可】

Unknown   
Copyright © 2023 Liu, Raab, Gui and Rudd