Recent Advances and Prospects in the Research of Nascent Adhesions

Frontiers in Physiology

Ana-Sunčana Smith¹  Andreja Ambriović-Ristov²  Aleksandra Radenovic³  Bernd Henning Stumpf⁴ 

[1] Group for Computational Life Sciences, Division of Physical Chemistry, Ruđer Bošković Institute, Zagreb, Croatia;Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia;Laboratory of Nanoscale Biology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland;PULS Group, Institute for Theoretical Physics, Interdisciplinary Center for Nanostructured Films, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany;

关键词: nascent adhesions;    focal adhesions;    integrin activation;    integrin clustering;    superresolution microscopy;    modeling;   

DOI  :  10.3389/fphys.2020.574371

来源: DOAJ

【 摘 要 】

Nascent adhesions are submicron transient structures promoting the early adhesion of cells to the extracellular matrix. Nascent adhesions typically consist of several tens of integrins, and serve as platforms for the recruitment and activation of proteins to build mature focal adhesions. They are also associated with early stage signaling and the mechanoresponse. Despite their crucial role in sampling the local extracellular matrix, very little is known about the mechanism of their formation. Consequently, there is a strong scientific activity focused on elucidating the physical and biochemical foundation of their development and function. Precisely the results of this effort will be summarized in this article.

【 授权许可】

Unknown