Association between physical activity and episodic memory and the moderating effects of the apolipoprotein E ε4 allele and age

Frontiers in Aging Neuroscience

Neuroscience

Hyun Soo Kim¹  Young Min Choe²  Guk-Hee Suh²  Boung Chul Lee³  Jee Wook Kim³  Ihn-Geun Choi⁴  Jaeuk Hwang⁵  Dahyun Yi⁶ 

[1] Department of Laboratory Medicine, Hallym University Dongtan Sacred Heart Hospital, Gyeonggi, Republic of Korea;Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Korea;Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Gyeonggi, Republic of Korea;Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Korea;Department of Neuropsychiatry, Hallym University Hangang Sacred Heart Hospital, Seoul, Republic of Korea;Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Korea;Department of Psychiatry, Seoul W Psychiatric Office, Seoul, Republic of Korea;Department of Psychiatry, Soonchunhyang University Hospital Seoul, Seoul, Republic of Korea;Institute of Human Behavioral Medicine, Medical Research Center Seoul National University, Seoul, Republic of Korea;

关键词: physical activity;    memory;    Alzheimer’s disease;    age;    APOE4;   

DOI  :  10.3389/fnagi.2023.1184609

 received in 2023-03-12, accepted in 2023-06-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundAn abundance of evidence indicates that physical activity may protect against Alzheimer’s disease (AD) and related cognitive decline. However, little is known about the association between physical activity and AD-related cognitive decline according to age and the apolipoprotein E (APOE) ε4 allele (APOE4) as major risk factors. Therefore, we examined whether age and APOE4 status modulate the effects of physical activity on episodic memory as AD-related cognition in non-demented older adults.MethodsWe enrolled 196 adults aged between 65 and 90 years, with no dementia. All participants underwent comprehensive clinical assessments including physical activity evaluation and APOE genotyping. The AD-related cognitive domain was assessed by the episodic memory, as the earliest cognitive change in AD, and non-memory cognition for comparative purposes. Overall cognition was assessed by the total score (TS) of the Consortium to Establish a Registry for Alzheimer’s Disease neuropsychological battery.ResultsWe found significant physical activity × age and physical activity × APOE4 interaction effects on episodic memory. Subgroup analyses indicated that an association between physical activity and increased episodic memory was apparent only in subjects aged > 70 years, and in APOE4-positive subjects.ConclusionOur findings suggest that physical activity has beneficial effects on episodic memory, as an AD-related cognitive domain, in individuals aged > 70 years and in APOE4-positive individuals. Physicians should take age and APOE4 status account into when recommending physical activity to prevent AD-related cognitive decline.

【 授权许可】

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Copyright © 2023 Lee, Choe, Suh, Choi, Kim, Hwang, Yi and Kim.