Non-Aβ-Dependent Factors Associated with Global Cognitive and Physical Function in Alzheimer’s Disease: A Pilot Multivariate Analysis

Journal of Clinical Medicine

Stefano Tamburin¹  Anna Pedrinolla¹  Cristina Fonte¹  Massimo Venturelli¹  Nicola Smania¹  Federico Schena¹  MaryAnna Venneri²  Fabio Naro²  Ilaria Boscolo Galazzo³  Barbara Ghinassi⁴  Angela Di Baldassarre⁴  Mario Rende⁵  AnnaMaria Stabile⁵  Ettore Muti⁶  FrancescaBenedetta Pizzini⁷ 

[1] Departement of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Via Casorati 43, 37127 Verona, Italy;Department of Anatomical, Histological, Forensic Medicine and Orthopedic Science, 00185 Rome, Italy;Department of Computer Science, University of Verona, 37134 Verona, Italy;Department of Medicine and Aging Sciences, University G. d’Annunzio, Chieti-Pescara, 66100 Chieti, Italy;Department of Surgical and Biomedical Sciences, Section of Human Anatomy, School of Medicine, University of Perugia, 06123 Perugia, Italy;Mons. Mazzali Foundation, 46100 Mantua, Italy;Neuroradiology, Department of Diagnostics and Pathology, Verona University Hospital, 37134 Verona, Italy;

关键词: Alzheimer’s disease;    mild cognitive impairment;    dementia;    exercise;    memory;    physical activity;   

DOI  :  10.3390/jcm8020224

来源: DOAJ

【 摘 要 】

Recent literature highlights the importance of identifying factors associated with mild cognitive impairment (MCI) and Alzheimer’s Disease (AD). Actual validated biomarkers include neuroimaging and cerebrospinal fluid assessments; however, we investigated non-Aβ-dependent factors associated with dementia in 12 MCI and 30 AD patients. Patients were assessed for global cognitive function (Mini-Mental state examination—MMSE), physical function (Physical Performance Test—PPT), exercise capacity (6-min walking test—6MWT), maximal oxygen uptake (VO₂max), brain volume, vascular function (flow-mediated dilation—FMD), inflammatory status (tumor necrosis factor—α ,TNF- α, interleukin-6, -10 and -15) and neurotrophin receptors (p75NTR and Tropomyosin receptor kinase A -TrkA). Baseline multifactorial information was submitted to two separate backward stepwise regression analyses to identify the variables associated with cognitive and physical decline in demented patients. A multivariate regression was then applied to verify the stepwise regression. The results indicated that the combination of 6MWT and VO₂max was associated with both global cognitive and physical function (MMSE = 11.384 + (0.00599 × 6MWT) − (0.235 × VO₂max)); (PPT = 1.848 + (0.0264 × 6MWT) + (19.693 × VO₂max)). These results may offer important information that might help to identify specific targets for therapeutic strategies (NIH Clinical trial identification number NCT03034746).

【 授权许可】

Unknown