A novel vaccine formulation candidate based on lipooligosaccharides and pertussis toxin against Bordetella pertussis

Frontiers in Immunology

Immunology

Linlin Huang¹  Jingjing Gao²  Fanglei Liu²  Shuquan Luo²  Ruijie Qiao²  Xin Li³ 

[1] Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, China;The First R&D Laboratory, Lanzhou Institute of Biological Products Company Limited, Lanzhou, China;The First R&D Laboratory, Lanzhou Institute of Biological Products Company Limited, Lanzhou, China;State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China;

关键词: Bordetella pertussis;    lipooligosaccharides;    conjugate vaccine;    pertussis toxin;    Protection;   

DOI  :  10.3389/fimmu.2023.1124695

 received in 2023-01-04, accepted in 2023-04-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

Pertussis is a severe human respiratory tract infectious disease caused by Bordetella pertussis that primarily affects infants and young children. However, the acellular pertussis vaccine currently administered can induce antibody and Th2 immune responses but fails to prevent the nasal colonization and transmission of B. pertussis, causing a resurgence of pertussis, so improved pertussis vaccines are urgently needed. In this study, we created a two-component pertussis vaccine candidate containing a conjugate prepared from oligosaccharides and pertussis toxin. After demonstrating the ability of the vaccine to induce a mixed Th1/Th2/Th17 profile in a mouse model, the strong in vitro bactericidal activity and IgG response of the vaccine were further demonstrated. In addition, the vaccine candidate further induced efficient prophylactic effects against B. pertussis in a mouse aerosol infection model. In summary, the vaccine candidate in this paper induces antibodies with bactericidal activity to provide high protection, shorten the duration of bacterial existence, and further reduce disease outbreaks. Therefore, the vaccine has the potential to be the next generation of pertussis vaccines.

【 授权许可】

Unknown   
Copyright © 2023 Gao, Huang, Luo, Qiao, Liu and Li