Keratinoctye-neuro-immune-units (KNICUs): collaborative impact on the initiation and maintenance of psoriasis

Frontiers in Medicine

Medicine

Yuan Zhou¹  Li-Ran Ye¹  Xue-Yan Chen¹  Zhao-Yuan Wang¹  Xiao-Yong Man² 

[1] Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;null;

关键词: psoriasis;    epidermal immunological microenvironment;    keratinocyte;    immunocyte;    neuron;   

DOI  :  10.3389/fmed.2023.1191057

 received in 2023-03-21, accepted in 2023-05-15,  发布年份 2023

来源: Frontiers

【 摘 要 】

The skin is the outermost barrier that separates the human body from the external environment. In psoriasis, immune cells reside within or infiltrate the epidermis to form the epidermal (epithelial) immunological microenvironment (EIME) and engage in complex interactions with keratinocytes, nerves, and microbiota. The proposed hypothesis is that psoriasis is a chronic inflammatory disease mainly mediated by a specific inflammatory environment composed of keratinocyte–neuro–immune cell units (KNICUs). These KNICUs arise from the interaction between activated epidermal keratinocytes, nerves, immune cells, and the skin microbiota, forming a complex interaction framework. Multiple units gather to complete the circulatory and amplified loops, consequently serving as a group army to initiate and maintain psoriasis.

【 授权许可】

Unknown   
Copyright © 2023 Chen, Wang, Zhou, Ye and Man.