Psoriasis immunometabolism: progress on metabolic biomarkers and targeted therapy

Frontiers in Molecular Biosciences

Molecular Biosciences

Polytimi Sidiropoulou¹  Gottfried Rudofsky²  George Evangelou³  Sabine Krueger-Krasagakis³  Aristidis Tsatsakis⁴  Evangelia Sarandi⁵  Dimitris Tsoukalas⁶  Nikolaos Drakoulis⁷  Maria Sifaki⁷ 

[1] 1st Department of Dermatology-Venereology, Faculty of Medicine, “A. Sygros” Hospital, National and Kapodistrian University of Athens, Athens, Greece;Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece;Clinic of Endocrinology and Metabolic Disorders, Cantonal Hospital Olten, Olten, Switzerland;Dermatology Department, University Hospital of Heraklion, Heraklion, Greece;Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, Heraklion, Greece;Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, Heraklion, Greece;Metabolomic Medicine, Health Clinics for Autoimmune and Chronic Diseases, Athens, Greece;Metabolomic Medicine, Health Clinics for Autoimmune and Chronic Diseases, Athens, Greece;European Institute of Molecular Medicine, Rome, Italy;Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece;

关键词: psoriasis;    T cell;    keratinocyte;    glycolysis;    lipid metabolism;    TCA;    biomarkers;    metabolic targets;   

DOI  :  10.3389/fmolb.2023.1201912

 received in 2023-04-07, accepted in 2023-06-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

Psoriasis is a common inflammatory disease that affects mainly the skin. However, the moderate to severe forms have been associated with several comorbidities, such as psoriatic arthritis, Crohn’s disease, metabolic syndrome and cardiovascular disease. Keratinocytes and T helper cells are the dominant cell types involved in psoriasis development via a complex crosstalk between epithelial cells, peripheral immune cells and immune cells residing in the skin. Immunometabolism has emerged as a potent mechanism elucidating the aetiopathogenesis of psoriasis, offering novel specific targets to diagnose and treat psoriasis early. The present article discusses the metabolic reprogramming of activated T cells, tissue-resident memory T cells and keratinocytes in psoriatic skin, presenting associated metabolic biomarkers and therapeutic targets. In psoriatic phenotype, keratinocytes and activated T cells are glycolysis dependent and are characterized by disruptions in the TCA cycle, the amino acid metabolism and the fatty acid metabolism. Upregulation of the mammalian target of rapamycin (mTOR) results in hyperproliferation and cytokine secretion by immune cells and keratinocytes. Metabolic reprogramming through the inhibition of affected metabolic pathways and the dietary restoration of metabolic imbalances may thus present a potent therapeutic opportunity to achieve long-term management of psoriasis and improved quality of life with minimum adverse effects.

【 授权许可】

Unknown   
Copyright © 2023 Sarandi, Krueger-Krasagakis, Tsoukalas, Sidiropoulou, Evangelou, Sifaki, Rudofsky, Drakoulis and Tsatsakis.