Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs

Frontiers in Immunology

Immunology

Hideo Yagita¹  Abdulkader Azouz²  Oberdan Leo³  Natalia Bowakim-Anta³  Valérie Acolty³  Guillaume Oldenhove³  Muriel Moser³  Stanislas Goriely⁴ 

[1] Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;Institute for Medical Immunology, Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Gosselies, Belgium;Laboratory of Immunobiology, Université Libre de Bruxelles (ULB), Gosselies, Belgium;Laboratory of Immunobiology, Université Libre de Bruxelles (ULB), Gosselies, Belgium;Institute for Medical Immunology, Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Gosselies, Belgium;

关键词: CD27 costimulation;    regulatory T cells;    dendritic cells;    eomes;    CXCR3;   

DOI  :  10.3389/fimmu.2023.1023064

 received in 2022-08-19, accepted in 2023-02-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionMost T lymphocytes, including regulatory T cells, express the CD27 costimulatory receptor in steady state conditions. There is evidence that CD27 engagement on conventional T lymphocytes favors the development of Th1 and cytotoxic responses in mice and humans, but the impact on the regulatory lineage is unknown.MethodsIn this report, we examined the effect of constitutive CD27 engagement on both regulatory and conventional CD4+ T cells in vivo, in the absence of intentional antigenic stimulation.ResultsOur data show that both T cell subsets polarize into type 1 Tconvs or Tregs, characterized by cell activation, cytokine production, response to IFN-γ and CXCR3-dependent migration to inflammatory sites. Transfer experiments suggest that CD27 engagement triggers Treg activation in a cell autonomous fashion.ConclusionWe conclude that CD27 may regulate the development of Th1 immunity in peripheral tissues as well as the subsequent switch of the effector response into long-term memory.

【 授权许可】

Unknown   
Copyright © 2023 Bowakim-Anta, Acolty, Azouz, Yagita, Leo, Goriely, Oldenhove and Moser