期刊论文详细信息
Frontiers in Cell and Developmental Biology
Elucidating a fresh perspective on the interplay between exosomes and rheumatoid arthritis
Cell and Developmental Biology
Wanting Meng1  Jing Hu2  Jianan Zhao3  Binbin Zhang4 
[1] Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China;Department of Nephropathy, The Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China;Department of Nephropathy, The Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China;Department of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China;Arthritis Institute of Integrated Traditional and Western Medicine, Shanghai Chinese Medicine Research Institute, Shanghai, China;Zhejiang University of Traditional Chinese Medicine, Hangzhou, China;Department of Translational Medicine Platform, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China;
关键词: rheumatoid arthritis;    exosomes;    microbial communities;    blood;    mesenchymal stem cells;    fibroblast-like synovial cells;    gut microbe-derived exosomes;   
DOI  :  10.3389/fcell.2023.1177303
 received in 2023-03-01, accepted in 2023-04-11,  发布年份 2023
来源: Frontiers
PDF
【 摘 要 】

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by chronic synovitis and the destruction of bones and joints. Exosomes are nanoscale lipid membrane vesicles originating from multivesicular bodies and are used as a vital means of intercellular communication. Both exosomes and the microbial community are essential in RA pathogenesis. Multiple types of exosomes from different origins have been demonstrated to have effects on various immune cells through distinct mechanisms in RA, which depend on the specific cargo carried by the exosomes. Tens of thousands of microorganisms exist in the human intestinal system. Microorganisms exert various physiological and pathological effects on the host directly or through their metabolites. Gut microbe-derived exosomes are being studied in the field of liver disease; however, information on their role in the context of RA is still limited. Gut microbe-derived exosomes may enhance autoimmunity by altering intestinal permeability and transporting cargo to the extraintestinal system. Therefore, we performed a comprehensive literature review on the latest progress on exosomes in RA and provided an outlook on the potential role of microbe-derived exosomes as emerging players in clinical and translational research on RA. This review aimed to provide a theoretical basis for developing new clinical targets for RA therapy.

【 授权许可】

Unknown   
Copyright © 2023 Zhao, Zhang, Meng and Hu.

【 预 览 】
附件列表
Files Size Format View
RO202310108746736ZK.pdf 977KB PDF download
  文献评价指标  
  下载次数:3次 浏览次数:1次