Relationship of Blood Serum Rheological Propertieswith the State of Autonomic Neural System in Rheumatoid Arthritis

Bolʹ, Sustavy, Pozvonočnik

O.P. Sokrut¹  A.V. Perepada¹  V.N. Sokrut¹  O.V. Syniachenko¹  E.D. Iegudina² 

[1] Donetsk National Medical University, Lyman, Ukraine;State Institution «Dnipropetrovsk Medical Academy», Dnipro, Ukraine;

关键词: rheumatoid arthritis;    autonomic neural system;    blood;    rheology;   

DOI  :  10.22141/2224-1507.4.24.2016.94621

来源: DOAJ

【 摘 要 】

Background. Rheumatoid arthritis (RA) belongs to the most common inflammatory diseases of the joints, and the number of these patients is increasing everywhere causing enormous medical, social and economic damage. An important role in the pathogenesis of RA is given to the violations of the autonomic neural system (ANS) functions, whose condition is closely related to the rheological properties of the blood serum (RPBS). The purpose and objectives. To evaluate the correlation between «vegetative passport» of RA patients and autonomic dysfunction with RPBS at different variations of the disease. Materials and methods. We have examined 173 patients aged 18 to 79 years (on the average 46 years), among them 21 % were males and 79 % — females. The duration of disease manifestation was 10 years, type of RA seropositive for rheumatoid factor and citrulline antibodies was detected in 3/4 of cases, extraarticular (systemic) form of the disease was diagnosed in 37 % of cases. The surface indicators of the blood serum — viscosity, elasticity, tension, relaxation and viscoelasticity modulus — were determined using digital tensio­meter PAT2-Sinterface (Germany). Results. «Ve­getative passport» defines the integral clinical, laboratory and instrumental signs of RA, wherein the severity of autono­mic dysfunction is directly correlated with the rate of joint pathology progression, and in sympathicotonia — with the baseline parameters of rheumatoid factor in the blood and the degree of RA activity. Changes in RPBS are accompanied by an increase in the steady-state (static) surface tension, which are recorded in 70 % of cases. Integral state of interfacial activity, relaxation and viscoelastic characteristics of the blood determine the type of ANS and the presence of autonomic dysfunction in patients (patients with vagotonia are characterized by increase in viscoelastic modulus and decrease of surface tension, with sympathicotonia — by increase in surface tension and reduced surface viscosity). RPBS parameters are associated with the severity of autonomic disorders, and the surface viscosity index has a prognostic value. Conclusions. The development of autonomic dysfunction is correlated not only with the features of the course of articular syndrome and extraarticular RA symptoms, but also with the state of ANS, which is involved in RPBS disorders. In the future, the assessment of ANS state will be useful for subsequent timely rehabi­litation measures of the disease.

【 授权许可】

Unknown