Relationship between serum uric acid and estimated glomerular filtration rate in adolescents aged 12-19 years with different body mass indices: a cross-sectional study

Frontiers in Endocrinology

Endocrinology

Yi-Cheng Fu¹  Qingnan He²  Zisai Wang²  Qiuwei Tian²  Mingyi Zhao²  Marady Hun²  Caixia He² 

[1] Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China;Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China;

关键词: serum uric acid;    estimated glomerular filtration rate;    BMI;    adolescents;    NHANES;   

DOI  :  10.3389/fendo.2023.1138513

 received in 2023-01-05, accepted in 2023-06-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundGlobally, chronic kidney disease (CKD) is a growing public health concern. Serum uric acid (SUA) is an easily detectable and readily available biochemical indicator that has long been recognized as an independent risk factor for CKD. In addition, studies have indicated a potential relationship between SUA and body mass index (BMI). However, studies on the effect of SUA levels on the estimated glomerular filtration rate (eGFR) in adolescents with different BMIs are very rare.MethodsWeighted multiple regression analysis was used to estimate the independent relationship between SUA and log-transformed eGFR. Additionally, we used a weighted generalized additive model and smooth curve fitting to describe the nonlinear relationships in the subgroup analysis.ResultsFirst, SUA was negatively associated with log-transformed eGFR even after adjusting for all covariates (β=-0.0177, 95% CI: -0.0203-0.0151, P<0.0001). Second, the results of the stratified analysis found that after adjusting for all covariates, the decrease in log-transformed eGFR due to changes in per SUA levels (Per 1, mg/dL increase) was elevated in female adolescents (β=-0.0177, 95% CI: -0.0216, -0.0138, P<0.0001), adolescents aged 12-15 years (β=-0.0163, 95% CI: -0.0200, -0.0125, P<0.0001) and black (β=-0.0199, 95% CI: -0.0251, -0.0148, P<0.0001) adolescents. Furthermore, we found that adolescents with a higher BMI had higher SUA levels, and the effect of SUA on eGFR was significantly higher in underweight adolescents (β=-0.0386, 95% CI: (-0.0550, -0.0223), P<0.0001).ConclusionSUA was negatively associated with the eGFR in adolescents aged 12-19 years. Furthermore, we found for the first time that SUA affects the eGFR differently in adolescents with different BMIs. This effect was particularly significant in underweight adolescents.

【 授权许可】

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Copyright © 2023 Tian, He, Wang, Hun, Fu, Zhao and He