Nutrients, herbal bioactive derivatives and commensal microbiota as tools to lower the risk of SARS-CoV-2 infection

Frontiers in Nutrition

Nutrition

Mauro Vaccarezza¹  Lorenzo Caruso²  Arianna Romani²  Giada Lodi²  Rebecca Voltan²  Maurizio Previati³  Enrico Zauli³  Domenico Sergi³  Giorgio Zauli⁴ 

[1] Curtin Medical School & Curtin Health Innovation Research Institute (CHIRI), Faculty of Health Sciences, Curtin University, Perth, WA, Australia;Department of Environmental and Prevention Sciences and LTTA Centre, University of Ferrara, Ferrara, Italy;Department of Translational Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy;Research Department, King Khaled Eye Specialistic Hospital, Riyadh, Saudi Arabia;

关键词: SARS-CoV-2;    COVID-19;    natural products;    phytochemicals;    ACE-2;    TMPRSS2;   

DOI  :  10.3389/fnut.2023.1152254

 received in 2023-01-27, accepted in 2023-05-15,  发布年份 2023

来源: Frontiers

【 摘 要 】

The SARS-CoV-2 outbreak has infected a vast population across the world, causing more than 664 million cases and 6.7 million deaths by January 2023. Vaccination has been effective in reducing the most critical aftermath of this infection, but some issues are still present regarding re-infection prevention, effectiveness against variants, vaccine hesitancy and worldwide accessibility. Moreover, although several old and new antiviral drugs have been tested, we still lack robust and specific treatment modalities. It appears of utmost importance, facing this continuously growing pandemic, to focus on alternative practices grounded on firm scientific bases. In this article, we aim to outline a rigorous scientific background and propose complementary nutritional tools useful toward containment, and ultimately control, of SARS-CoV-2 infection. In particular, we review the mechanisms of viral entry and discuss the role of polyunsaturated fatty acids derived from α-linolenic acid and other nutrients in preventing the interaction of SARS-CoV-2 with its entry gateways. In a similar way, we analyze in detail the role of herbal-derived pharmacological compounds and specific microbial strains or microbial-derived polypeptides in the prevention of SARS-CoV-2 entry. In addition, we highlight the role of probiotics, nutrients and herbal-derived compounds in stimulating the immunity response.

【 授权许可】

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Copyright © 2023 Romani, Sergi, Zauli, Voltan, Lodi, Vaccarezza, Caruso, Previati and Zauli.