Regulation of iron metabolism and ferroptosis in cancer stem cells

Frontiers in Oncology

Oncology

Qian Yan¹  Jinwei Cui¹  Yubin Chen¹  Shiye Ruan²  Zhongyan Zhang²  Baohua Hou³  Shanzhou Huang³  Xinjian Wang⁴  Hailiang Wang⁵ 

[1] Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China;Department of General Surgery, Heyuan People’s Hospital, Heyuan, China;Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China;The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China;Department of General Surgery, Heyuan People’s Hospital, Heyuan, China;Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China;The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China;Department of General Surgery, Heyuan People’s Hospital, Heyuan, China;Department of General Surgery, South China University of Technology School of Medicine, Guangzhou, China;Department of Hepatobiliary Surgery, Weihai Central Hospital Affiliated to Qingdao University, Weihai, China;Department of Hepatobiliary Surgery, Weihai Central Hospital Affiliated to Qingdao University, Weihai, China;Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China;The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China;

关键词: CSCs;    ferroptosis;    iron metabolism;    lipid peroxidation;    GPX4-GSH;    FSP1-CoQ10;   

DOI  :  10.3389/fonc.2023.1251561

 received in 2023-07-03, accepted in 2023-08-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

The ability of cancer stem cells (CSCs) to self-renew, differentiate, and generate new tumors is a significant contributor to drug resistance, relapse, and metastasis. Therefore, the targeting of CSCs for treatment is particularly important. Recent studies have demonstrated that CSCs are more susceptible to ferroptosis than non-CSCs, indicating that this could be an effective strategy for treating tumors. Ferroptosis is a type of programmed cell death that results from the accumulation of lipid peroxides caused by intracellular iron-mediated processes. CSCs exhibit different molecular characteristics related to iron and lipid metabolism. This study reviews the alterations in iron metabolism, lipid peroxidation, and lipid peroxide scavenging in CSCs, their impact on ferroptosis, and the regulatory mechanisms underlying iron metabolism and ferroptosis. Potential treatment strategies and novel compounds targeting CSC by inducing ferroptosis are also discussed.

【 授权许可】

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Copyright © 2023 Wang, Zhang, Ruan, Yan, Chen, Cui, Wang, Huang and Hou