The mechanisms crosstalk and therapeutic opportunities between ferroptosis and ovary diseases

Frontiers in Endocrinology

Endocrinology

Yulan Li¹  Bin Wang²  Ying Yao²  Yanbiao Jiang²  Hong Guo² 

[1] Department of Anesthesiology, The First Hospital of Lanzhou University, Lanzhou, China;The First School of Clinical Medicine, Lanzhou University, Lanzhou, China;

关键词: ovarian diseases;    ferroptosis;    iron metabolism;    lipid peroxidation;    therapeutics;   

DOI  :  10.3389/fendo.2023.1194089

 received in 2023-03-26, accepted in 2023-06-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

Ferroptosis, a form of regulated cell death, was first defined in 2012. Ferroptosis mainly involves iron-driven lipid peroxidation damage of cells. This process is regulated by iron homeostasis, redox balance, lipid metabolism, glutathione metabolism, and various disease signaling pathways. Iron is one of the key mineral elements that regulate the physiological function of women and the development of ovarian tumors. Occurrence of Ferroptosis has some hidden dangers and advantages in ovary diseases. Some scholars have shown that ferroptosis of ovarian granulosa cells (GC) promotes the development of ovarian dysfunction and polycystic ovary syndrome (PCOS). Interestingly, drug-resistant ovarian cancer cells are very sensitive to ferroptosis, suggesting that pharmacological positive and negative regulation of ferroptosis has great potential in the treatment of benign ovarian diseases and ovarian cancer. This article aimed to assess how ferroptosis occurs and the factors controlling ferroptosis. Moreover, we summarize how ferroptosis can be used to predict, diagnose and target treatment ovary disease. Meanwhile, we also evaluated the different phenomena of Ferroptosis in ovarian diseases. It aims to provide new directions for the research and prevention of female reproductive diseases.

【 授权许可】

Unknown   
Copyright © 2023 Yao, Wang, Jiang, Guo and Li