Case report: Thyroid sarcoidosis as a rare localization of the disease: Report of two cases and review of the literature

Frontiers in Medicine

Medicine

Jovan Javorac¹  Svetlana Kašiković Lečić¹  Dejan Živanović²  Jelena Đokić³  Danica Sazdanić Velikić⁴  Aleksandra Lovrenski⁵ 

[1]Department of Internal Medicine, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia

[2]Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia

[3]Department of Psychology, College of Social Work, Belgrade, Serbia

[4]Department of Medical Sciences, College of Vocational Studies “Sirmium”, Sremska Mitrovica, Serbia

[5]Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia

[6]Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia

[7]Department of Geriatrics, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia

[8]Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia

[9]Department of Pathology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia

关键词: sarcoidosis;    thyroid;    prevalence;    diagnosis;    treatment;   

DOI  :  10.3389/fmed.2023.1046420

 received in 2022-09-16, accepted in 2023-02-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

Sarcoidosis is a multi-systemic disease of unknown etiology that is characterized by the formation of non-necrotizing and non-caseating granulomas in affected organs. Sarcoidosis granulomas can form in any organ, but the lungs and intrathoracic lymph nodes are the most commonly affected. Thyroid involvement in sarcoidosis is very rare, with prevalence estimates of 1–4.5% in case series of autopsied patients with systemic sarcoidosis. It is extremely rare for sarcoidosis to occur solely in the thyroid gland, but it is usually associated with the involvement of other organs, primarily the lungs and lymph nodes. Typical manifestations are diffuse goiter and solitary or multiple thyroid nodules. Thyroid function remains intact in the majority of cases, but sometimes it can result in hypothyroidism or hyperthyroidism. The diagnosis can be made after fine needle aspiration cytology, but usually it is diagnosed as an incidental finding while analyzing thyroidectomy tissue or during autopsy. Oral steroids are the cornerstone of thyroid sarcoidosis management, along with specific endocrinological treatment on some occasions. Given that we found only 71 reports of thyroid sarcoidosis available in the literature, we created and analyzed a cohort of 24 patients with thyroid sarcoidosis who were described in the literature in the 21st century and reported two additional cases of thyroid sarcoidosis.

【 授权许可】

Unknown   
Copyright © 2023 Kašiković Lečić, Javorac, Lovrenski, Đokić, Sazdanić Velikić and Živanović.