期刊论文详细信息
Frontiers in Endocrinology
The relationship between triglyceride-glucose index and albuminuria in United States adults
Endocrinology
Han Qian1  Zhaoxiang Wang2  Shao Zhong2  Qichao Yang3  Mengjiao Xu3  Tian Gu3 
[1] Department of Cardiology, Affiliated Taicang Hospital of Soochow University, Suzhou, Jiangsu, China;Department of Endocrinology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, China;Department of Endocrinology, Affiliated Wujin Hospital of Jiangsu University, Changzhou, Jiangsu, China;
关键词: triglyceride-glucose index;    insulin resistance;    metabolic syndrome;    albuminuria;    NHANES;   
DOI  :  10.3389/fendo.2023.1215055
 received in 2023-05-01, accepted in 2023-08-07,  发布年份 2023
来源: Frontiers
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【 摘 要 】

PurposeTriglyceride-glucose (TyG) index is a simple and reliable indicator of metabolic dysfunction. We aimed to investigate a possible relationship between TyG index and albuminuria in the United States adult population.MethodsThis cross-sectional study was conducted among adults with complete TyG index and urinary albumin/urinary creatinine (UACR) from 2011-2018 National Health and Nutrition Examination Survey (NHANES). The independent relationship between TyG index and albuminuria (UACR>30mg/g) was evaluated. TyG index was compared with insulin resistance represented by homeostatic model assessment of insulin resistance (HOMA-IR), and metabolic syndrome. Subgroup analysis was also performed.ResultsA total of 9872 participants were included in this study, and the average TyG index was 8.53 ± 0.01. The proportion of albuminuria gradually increased with the increase of TyG index quartile interval. Elevated TyG index was independently associated with albuminuria, and this association persisted after additional adjustments for HOMA-IR or dichotomous metabolic syndrome. The area under the ROC curve (AUC) of TyG index was larger than that of log (HOMA-IR). Subgroup analysis suggested that the relationship between TyG index and albuminuria is of greater concern in age<60, overweight/obese, diabetic, and metabolic syndrome patients.ConclusionThe TyG index may be a potential epidemiological tool to quantify the role of metabolic dysfunction, rather than just insulin resistance, in albuminuria in the United States adult population. Further large-scale prospective studies are needed to confirm our findings.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Qian, Zhong, Gu, Xu and Yang

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