Molecular mechanisms of osteosarcoma metastasis and possible treatment opportunities

Frontiers in Oncology

Oncology

Lon Kai Pang¹  Zhehuang Li²  Xinhui Du²  Boya Zhang²  Bangmin Wang²  Weitao Yao²  Hua Wei³  Ruiying Zhao⁴ 

[1] Baylor College of Medicine, Houston, TX, United States;Bone Soft Tissue Department, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China;Key Laboratory for Digital Assessment of Spinal-Pelvic Tumor and Surgical Aid Tools Design (Zhengzhou), Zhengzhou, Henan, China;Key Laboratory for Perioperative Digital Assessment of Bone Tumors (Henan), Zhengzhou, Henan, China;Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China;Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States;

关键词: osteosarcoma;    metastasis;    reprogramming;    tumor microenvironment;    mechanism;   

DOI  :  10.3389/fonc.2023.1117867

 received in 2022-12-07, accepted in 2023-04-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

In osteosarcoma patients, metastasis of the primary cancer is the leading cause of death. At present, management options to prevent metastasis are limited and non-curative. In this study, we review the current state of knowledge on the molecular mechanisms of metastasis and discuss promising new therapies to combat osteosarcoma metastasis. Genomic and epigenomic changes, metabolic reprogramming, transcription factors, dysregulation of physiologic pathways, and alterations to the tumor microenvironment are some of the changes reportedly involved in the regulation of osteosarcoma metastasis. Key factors within the tumor microenvironment include infiltrating lymphocytes, macrophages, cancer-associated fibroblasts, platelets, and extracellular components such as vesicles, proteins, and other secreted molecules. We conclude by discussing potential osteosarcoma-limiting agents and their clinical studies.

【 授权许可】

Unknown   
Copyright © 2023 Du, Wei, Zhang, Wang, Li, Pang, Zhao and Yao