Hypoxia-induced cancer cell reprogramming: a review on how cancer stem cells arise

Frontiers in Oncology

Oncology

Genevieve M. Abd¹  Yong Li¹  Jennifer C. Ku²  Madison C. Laird² 

[1] Department of Orthopedic Surgery, Biomedical. Engineering, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI, United States;Medical Students, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI, United States;

关键词: reprogramming;    cancer stem cells;    Yamanaka factors;    metastasis;    hypoxia;   

DOI  :  10.3389/fonc.2023.1227884

 received in 2023-05-23, accepted in 2023-07-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cancer stem cells are a subset of cells within the tumor that possess the ability to self-renew as well as differentiate into different cancer cell lineages. The exact mechanisms by which cancer stem cells arise is still not completely understood. However, current research suggests that cancer stem cells may originate from normal stem cells that have undergone genetic mutations or epigenetic changes. A more recent discovery is the dedifferentiation of cancer cells to stem-like cells. These stem-like cells have been found to express and even upregulate induced pluripotent stem cell markers known as Yamanaka factors. Here we discuss developments in how cancer stem cells arise and consider how environmental factors, such as hypoxia, plays a key role in promoting the progression of cancer stem cells and metastasis. Understanding the mechanisms that give rise to these cells could have important implications for the development of new strategies in cancer treatments and therapies.

【 授权许可】

Unknown   
Copyright © 2023 Abd, Laird, Ku and Li