Emerging evidence-based innovative approaches to control catheter-associated urinary tract infection: a review

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Rambabu Dandela¹  Shobana Rajaramon²  Adline Princy Solomon²  Karthi Shanmugam² 

[1]Department of Industrial and Engineering Chemistry, Institute of Chemical Technology, Bhubaneswar, Odisha, India

[2]Quorum Sensing Laboratory, Centre for Research in Infectious Diseases (CRID), School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, India

关键词: catheter-associated urinary tract infection;    surface modification;    urinary catheter coatings;    anti-fouling;    antimicrobial;    biofilm;   

DOI  :  10.3389/fcimb.2023.1134433

 received in 2022-12-30, accepted in 2023-07-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

Healthcare settings have dramatically advanced the latest medical devices, such as urinary catheters (UC) for infection, prevention, and control (IPC). The continuous or intermittent flow of a warm and conducive (urine) medium in the medical device, the urinary catheter, promotes the formation of biofilms and encrustations, thereby leading to the incidence of CAUTI. Additionally, the absence of an innate immune host response in and around the lumen of the catheter reduces microbial phagocytosis and drug action. Hence, the review comprehensively overviews the challenges posed by CAUTI and associated risks in patients’ morbidity and mortality. Also, detailed, up-to-date information on the various strategies that blended/tailored the surface properties of UC to have anti-fouling, biocidal, and anti-adhesive properties to provide an outlook on how they can be better managed with futuristic solutions.

【 授权许可】

Unknown   
Copyright © 2023 Rajaramon, Shanmugam, Dandela and Solomon