The associations between caffeine treatment and common preterm morbidities: a retrospective cohort analysis

Frontiers in Pediatrics

Pediatrics

Şerife Suna Oğuz¹  Hayriye Gözde Kanmaz Kutman¹  Özlem Bozkurt Kalyoncu²  Duygu Bidev³  Funda Yavanoglu Atay⁴ 

[1] Department of Pediatrics, Division of Neonatology, Ankara City Hospital, Ankara, Türkiye;Department of Pediatrics, Division of Neonatology, Kocaeli University Faculty of Medicine, Kocaeli, Türkiye;Department of Pediatrics, Division of Neonatology, Koru Hospital, Ankara, Türkiye;Department of Pediatrics, Division of Neonatology, Umraniye Research and Training Hospital, University of Health Sciences, Istanbul, Türkiye;

关键词: preterm;    respiratory distress;    morbidity;    caffeine;    bronchopulmonary dysplasia;   

DOI  :  10.3389/fped.2023.1178976

 received in 2023-03-03, accepted in 2023-06-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionCaffeine is one of the most used drugs in the neonatal intensive care units (NICUs). It is widely regarded as beneficial in preventing many morbidities by reducing apnea of prematurity and improving respiratory functions.MethodsPremature infants with gestational ages >25 and <32 weeks who were hospitalized in the NICU between 2008 and 2013 and survived up to discharge were retrospectively analyzed. Infants treated with prophylactic caffeine were compared with historical controls born in 2008 and did not receive caffeine treatment. Maternal and neonatal characteristics and common neonatal morbidities were recorded.ResultsA total of 475 patients were analyzed. The patients receiving caffeine were classified as Group 1 (n = 355), and the patients not receiving caffeine were classified as Group 2 (n = 120). Despite the higher incidence of respiratory distress syndrome requiring surfactant therapy and a longer duration of respiratory support in Group 2, the rates of bronchopulmonary dysplasia (BPD) and most other common morbidities were quite comparable. The frequency of apnea was statistically lower in the group that received caffeine prophylaxis (p < 0.01).ConclusionIn this retrospective cohort analysis, we found that caffeine prophylaxis significantly decreased apnea attacks however does not prevent respiratory morbidity such as BPD.

【 授权许可】

Unknown   
© 2023 Yavanoglu Atay, Kanmaz Kutman, Bidev, Bozkurt Kalyoncu and Oğuz.