Shared and divergent principles of synaptic transmission between cortical excitatory neurons in rodent and human brain

Frontiers in Synaptic Neuroscience

Neuroscience

Christiaan P. J. de Kock¹  Dirk Feldmeyer² 

[1] Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, Netherlands;Research Center Juelich, Institute of Neuroscience and Medicine, Jülich, Germany;Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University Hospital, Aachen, Germany;Jülich-Aachen Research Alliance, Translational Brain Medicine (JARA Brain), Aachen, Germany;

关键词: excitatory neurotransmission;    rodent;    primate;    human;    synapse;    EPSP;    neocortex;   

DOI  :  10.3389/fnsyn.2023.1274383

 received in 2023-08-08, accepted in 2023-08-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

Information transfer between principal neurons in neocortex occurs through (glutamatergic) synaptic transmission. In this focussed review, we provide a detailed overview on the strength of synaptic neurotransmission between pairs of excitatory neurons in human and laboratory animals with a specific focus on data obtained using patch clamp electrophysiology. We reach two major conclusions: (1) the synaptic strength, measured as unitary excitatory postsynaptic potential (or uEPSP), is remarkably consistent across species, cortical regions, layers and/or cell-types (median 0.5 mV, interquartile range 0.4–1.0 mV) with most variability associated with the cell-type specific connection studied (min 0.1–max 1.4 mV), (2) synaptic function cannot be generalized across human and rodent, which we exemplify by discussing the differences in anatomical and functional properties of pyramidal-to-pyramidal connections within human and rodent cortical layers 2 and 3. With only a handful of studies available on synaptic transmission in human, it is obvious that much remains unknown to date. Uncovering the shared and divergent principles of synaptic transmission across species however, will almost certainly be a pivotal step toward understanding human cognitive ability and brain function in health and disease.

【 授权许可】

Unknown   
Copyright © 2023 de Kock and Feldmeyer.