Single-cell sequencing technology in colorectal cancer: a new technology to disclose the tumor heterogeneity and target precise treatment

Frontiers in Immunology

Immunology

Zhiying Peng¹  Rongbo Wen¹  Guanyu Yu¹  Fuao Cao¹  Xianhua Gao¹  Leqi Zhou¹  Hang Jia¹  Wei Zhang¹  Tianshuai Zhang¹  Hao Fan¹  Liqiang Hao¹  Zheng Lou¹ 

[1] Department of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai, China;

关键词: colorectal cancer;    single-cell sequencing;    tumor heterogeneity;    tumor microenvironment;    precise treatment;   

DOI  :  10.3389/fimmu.2023.1175343

 received in 2023-02-27, accepted in 2023-04-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

Colorectal Cancer (CRC) is one of the most common gastrointestinal tumors, and its high tumor heterogeneity makes traditional sequencing methods incapable of obtaining information about the heterogeneity of individual cancer cells in CRC. Therefore, single-cell sequencing technology can be applied to better analyze the differences in genetic and protein information between cells, to obtain genomic sequence information of single cells, and to more thoroughly analyze the cellular characteristics and interactions in the CRC microenvironment. This will provide a more comprehensive understanding of colorectal cancer development and metastasis and indicate the treatment plan and prognosis. In this study, we review the application of single-cell sequencing to analyze the tumor microenvironment of CRC, explore the mechanisms involved in CRC metastasis and progression, and provide a reference for potential treatment options.

【 授权许可】

Unknown   
Copyright © 2023 Wen, Zhou, Peng, Fan, Zhang, Jia, Gao, Hao, Lou, Cao, Yu and Zhang