Research Progress of Single Cell Sequencing in Lung Cancer

Chinese Journal of Lung Cancer

Jinjing TAN¹  Jinghui WANG²  Mengjun YU³ 

[1] Beijing Chest Hospital, Capital Medical University, Beijing 101149, China;Department of Cellular and Molecular Biology, Beijing Tuberculosis and Thoracic Tumor Research Institute;Department of Medical Oncology, Beijing Tuberculosis and Thoracic Tumor Research Institute;

关键词: single-cell sequencing;    lung neoplasms;    tumor heterogeneity;    tumor microenvironment;    precision treatment;   

DOI  :  10.3779/j.issn.1009-3419.2021.102.04

来源: DOAJ

【 摘 要 】

Lung cancer is the malignant tumor with the highest mortality rate in the world. Heterogeneity of lung cancer, usually studied by sequencing technology, is considered to have important clinical significance in current studies. However, general sequencing technology can only explain the differences between samples integrally and its resolution is not enough to describe the differences between the individual cells. Therefore, people urgently hope to understand the cell type, state, subgroup distribution in the tumor microenvironment and the communication behavior between cells in the single cell level. Single-cell sequencing technology solves this problem. Using this technique will contribute to further understanding the mechanism of the occurrence and development of lung cancer, discovering new diagnostic markers and therapeutic targets, and providing theoretical references for the precise treatment of lung cancer patients in the future. This article reviews the progress of single-cell sequencing technology and focuses on its research on lung cancer tumor heterogeneity, tumor microenvironment, invasion and metastasis, treatment response, and drug resistance.

【 授权许可】

Unknown