Disposition of a single oral dose of a cannabidiol medication in healthy cats

Frontiers in Veterinary Science

Veterinary Science

Dawn M. Boothe¹  Crisanta Cruz-Espindola¹  Tom Jukier²  Doug Martin³ 

[1] Clinical Pharmacology Laboratory, Department of Anatomy and Physiology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States;Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, United States;Scott Ritchey Research Center, Department of Anatomy and Physiology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States;

关键词: cannabidiol;    CBD;    cat;    epilepsy;    seizures;   

DOI  :  10.3389/fvets.2023.1181517

 received in 2023-03-07, accepted in 2023-04-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

The historical use of the marijuana plant for medicinal purposes is long. One of the historical uses has been for the treatment of epilepsy. Recently, the Food and Drug Administration has approved a highly purified cannabidiol medication for the add on therapy in people with certain forms of epilepsy. With the increase interest of the use of cannabidiol in the veterinary community, the aim of this study was to describe the disposition of a single dose of a cannabidiol medication in healthy cats in both the fed and fasted state. Pharmacokinetic analysis reveals that relative bioavailability of cannabidiol shows a near eleven-fold increase when administered in the fed state compared to the fasted state. Additionally, concentrations achieved at a dose of 5 mg/kg, may be sufficient to explore the therapeutic potential in cats with epilepsy.

【 授权许可】

Unknown   
Copyright © 2023 Jukier, Cruz-Espindola, Martin and Boothe.