Prediction of ablation zone disappearance after microwave ablation for the patients with papillary thyroid microcarcinoma using nomograph

Frontiers in Endocrinology

Endocrinology

Jing Yang¹  Huahui Liu¹  Sainan Guan¹  Cai Hu¹  Shuang Liang¹  Haiyu Kang¹  Erjiao Xu¹  Ronghua Yan² 

[1] Department of Medical Ultrasonics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzen, China;Department of Radiology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China;Department of Radiology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzen, China;

关键词: papillary thyroid microcarcinoma (PTMC);    microwave ablation (MWA);    ablation zone;    disappearance;    nomograph;   

DOI  :  10.3389/fendo.2023.1145958

 received in 2023-01-16, accepted in 2023-04-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectivesTo construct a prognostic nomogram to predict the ablation zone disappearance for patients with papillary thyroid microcarcinoma (PTMC) after microwave ablation (MWA).Materials and methodsFrom April 2020 to April 2022, patients with PTMC who underwent MWA treatment were collected retrospectively. Ultrasound (US) or contrast-enhanced ultrasound (CEUS) was performed at 1 day, 1, 3, 6, 12, 18 and 24 months after MWA to observe the curative effect after ablation. The volume, volume reduction rate (VRR) and complete disappearance rate of the ablation zone at each time point were calculated. Univariate and multivariate logistic regression analysis were used to determine the prognostic factors associated with the disappearance of the ablation zone after MWA, and the nomogram was established and validated.Results72 patients with PTMCs underwent MWA were enrolled into this study. After MWA, no tumor progression (residual, recurrence or lymph node metastasis) and major postoperative complications occurred. The ablation zone in 28 (38.89%) patients did not completely disappear after MWA in the follow-up period. Three variables, including age (odds ratio [OR]: 1.216), calcification type (OR: 12.283), initial maximum diameter (OR: 2.051) were found to be independent prognostic factors predicting ablation zone status after MWA by multivariate analysis. The above variables and outcomes were visualized by nomogram (C-index=0.847).ConclusionsMWA was a safe and effective treatment for PTMC. Older patients with macrocalcification and larger size PTMCs were more unlikely to obtain complete disappearance of ablation zones. Incomplete disappearance of ablation zone was not related to recurrence.

【 授权许可】

Unknown   
Copyright © 2023 Hu, Liang, Liu, Yang, Kang, Guan, Yan and Xu