Differential effects of social isolation on oligodendrocyte development in different brain regions: insights from a canine model

Frontiers in Cellular Neuroscience

Neuroscience

Jidong Mi¹  Yuan Li¹  Yixue Li²  Liguang Yang³  Chao Guo⁴  Cirong Liu⁵  Hui Zhao⁶  Sin Man Lam⁶  Ying Xiong⁶  Huilin Hong⁶  Wei Ren⁷  Yong Q. Zhang⁷  Guanghou Shui⁷  Yan Zhuo⁸  Zhentao Zuo⁸  Xueru Liu⁸  Guo-Dong Wang⁹  Zhongyin Zhou⁹  Ya-Ping Zhang⁹ 

[1] Beijing Sinogene Biotechnology Co., Ltd., Beijing, China;Bio-Med Big Data Center, Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China;College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China;Bio-Med Big Data Center, Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China;Division of Life Sciences and Medicine, School of Life Sciences, University of Science and Technology of China, Hefei, China;State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China;Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China;Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, China;State Key Laboratory for Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China;State Key Laboratory for Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China;College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China;State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China;College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China;State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China;

关键词: social isolation;    dog;    oligodendrocyte;    myelin;    parietal cortex;    blood-brain barrier;   

DOI  :  10.3389/fncel.2023.1201295

 received in 2023-04-06, accepted in 2023-06-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

Social isolation (SI) exerts diverse adverse effects on brain structure and function in humans. To gain an insight into the mechanisms underlying these effects, we conducted a systematic analysis of multiple brain regions from socially isolated and group-housed dogs, whose brain and behavior are similar to humans. Our transcriptomic analysis revealed reduced expression of myelin-related genes specifically in the white matter of prefrontal cortex (PFC) after SI during the juvenile stage. Despite these gene expression changes, myelin fiber organization in PFC remained unchanged. Surprisingly, we observed more mature oligodendrocytes and thicker myelin bundles in the somatosensory parietal cortex in socially isolated dogs, which may be linked to an increased expression of ADORA2A, a gene known to promote oligodendrocyte maturation. Additionally, we found a reduced expression of blood-brain barrier (BBB) structural components Aquaporin-4, Occludin, and Claudin1 in both PFC and parietal cortices, indicating BBB disruption after SI. In agreement with BBB disruption, myelin-related sphingolipids were increased in cerebrospinal fluid in the socially isolated group. These unexpected findings show that SI induces distinct alterations in oligodendrocyte development and shared disruption in BBB integrity in different cortices, demonstrating the value of dogs as a complementary animal model to uncover molecular mechanisms underlying SI-induced brain dysfunction.

【 授权许可】

Unknown   
Copyright © 2023 Hong, Guo, Liu, Yang, Ren, Zhao, Li, Zhou, Lam, Mi, Zuo, Liu, Wang, Zhuo, Zhang, Li, Shui, Zhang and Xiong.