Transcriptional regulation of innate lymphoid cells and T cells by aryl hydrocarbon receptor

Frontiers in Immunology

Immunology

Eric Y. Helm¹  Liang Zhou¹ 

[1]Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL, United States

关键词: aryl hydrocarbon receptor;    helper T cell;    innate lymphoid cell;    transcriptional regulation;    chromatin;    epigenetics;   

DOI  :  10.3389/fimmu.2023.1056267

 received in 2022-09-28, accepted in 2023-03-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

The aryl hydrocarbon receptor (Ahr) is a ligand-dependent transcription factor and facilitates immune cell environmental sensing through its activation by cellular, dietary, and microbial metabolites, as well as environmental toxins. Although expressed in various cell types, Ahr in innate lymphoid cells (ILCs) and their adaptive T cell counterparts regulates essential aspects of their development and function. As opposed to T cells, ILCs exclusively rely on germ-line encoded receptors for activation, but often share expression of core transcription factors and produce shared effector molecules with their T cell counterparts. As such, core modules of transcriptional regulation are both shared and diverge between ILCs and T cells. In this review, we highlight the most recent findings regarding Ahr’s transcriptional regulation of both ILCs and T cells. Furthermore, we focus on insights elucidating the shared and distinct mechanisms by which Ahr regulates both innate and adaptive lymphocytes.

【 授权许可】

Unknown   
Copyright © 2023 Helm and Zhou