Mindfulness skills and experiential avoidance as therapeutic mechanisms for treatment-resistant depression through mindfulness-based cognitive therapy and lifestyle modification

Frontiers in Psychology

Psychology

Shannon Maloney¹  Jesús Montero-Marin²  Capilla Navarro-Guzmán³  Elena Gervilla⁴  María J. Serrano-Ripoll⁵  Alejandra Aguilar-Latorre⁶  Javier Garcia-Campayo⁷  Bárbara Oliván-Blázquez⁸  Andrea Seguí⁹  Aurora Garcia⁹  Rocío Gomez-Juanes⁹  Jose Antonio Marino⁹  Francisco Gazquez⁹  Mauro Garcia-Toro^1,10 

[1] Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom;Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom;Teaching, Research and Innovation Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain;Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiology and Public Health-CIBERESP), Madrid, Spain;Department of Psychology, University of the Balearic Islands, Palma, Spain;Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain;Department of Psychology, University of the Balearic Islands, Palma, Spain;Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain;Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), Carlos III Health Institute, Madrid, Spain;Primary Care Research Unit of Mallorca, Balearic Islands Health Services, Palma, Spain;Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), Carlos III Health Institute, Madrid, Spain;Institute for Health Research Aragón (IIS Aragón), Zaragoza, Spain;Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), Carlos III Health Institute, Madrid, Spain;Institute for Health Research Aragón (IIS Aragón), Zaragoza, Spain;Department of Medicine, Psychiatry and Dermatology, University of Zaragoza, Zaragoza, Spain;Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), Carlos III Health Institute, Madrid, Spain;Institute for Health Research Aragón (IIS Aragón), Zaragoza, Spain;Department of Psychology and Sociology, University of Zaragoza, Zaragoza, Spain;University Institute of Health Science Research (IUNICS), University of the Balearic Islands, Palma, Spain;Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain;University Institute of Health Science Research (IUNICS), University of the Balearic Islands, Palma, Spain;Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain;Department of Medicine, University of the Balearic Islands, Palma, Spain;Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), Carlos III Health Institute, Madrid, Spain;

关键词: major depressive disorder;    MBCT;    lifestyle modification;    mediation;    intervention;   

DOI  :  10.3389/fpsyg.2023.1008891

 received in 2022-08-02, accepted in 2023-02-15,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background/objectiveThe COVID-19 pandemic and consequent physical distancing has made it difficult to provide care for those with Treatment-Resistant Depression (TRD). As a secondary analysis of a clinical trial, the aim of this study was to explore potential mechanisms through which three online-delivered approaches, added to treatment as usual, improve depressive symptoms in TRD patients.MethodsThe three approaches included (a) Minimal Lifestyle Intervention (MLI), (b) Mindfulness-Based Cognitive Therapy (MBCT), and (c) Lifestyle Modification Program (LMP). Sixty-six participants with TRD completed assessments pre-post intervention (mindfulness skills [FFMQ]; self-compassion [SCS]; and experiential avoidance [AAQ-II]) and pre-intervention to follow-up (depressive symptoms [BDI-II]). Data were analyzed using within-subjects regression models to test mediation.ResultsMindfulness skills mediated the effect of MBCT on depressive symptoms (ab = −4.69, 95% CI = −12.93 to−0.32), whereas the lack of experiential avoidance mediated the effect of LMP on depressive symptoms (ab = −3.22, 95% CI = −7.03 to−0.14).ConclusionStrengthening mindfulness skills and decreasing experiential avoidance may promote recovery in patients with TRD, MBCT, and LMP have demonstrated that they may help increase mindfulness skills and decrease experiential avoidance, respectively. Future work will need to unpick the components of these interventions to help isolate active ingredients and increase optimization.

【 授权许可】

Unknown   
Copyright © 2023 Garcia-Toro, Aguilar-Latorre, Garcia, Navarro-Guzmán, Gervilla, Seguí, Gazquez, Marino, Gomez-Juanes, Serrano-Ripoll, Oliván-Blázquez, Garcia-Campayo, Maloney and Montero-Marin.