Applications of advances in mRNA-based platforms as therapeutics and diagnostics in reproductive technologies

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Junaid Kashir¹  Zakia Dimassi²  Sally M. Al-Qaraghuli³  Riwa Y. El Khatib³  Haia M. R. Abdulsamad³  Wjdan S. Bafleh³  Rawdah Taha Elbahrawi³  Azhar Mohamud Abdukadir³  Hamdan Hamdan⁴  Shaima M. Alsawae⁵ 

[1] Department of Biology, College of Arts and Science, Khalifa University, Abu Dhabi, United Arab Emirates;Department of Comparative Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia;Department of Pediatrics, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates;Department of Physiology and Immunology, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates;Department of Physiology and Immunology, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates;Healthcare Engineering Innovation Center (HEIC), Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates;null;

关键词: oocyte;    sperm;    embryo;    RNA;    oocyte activation;    calcium;    therapeutics;   

DOI  :  10.3389/fcell.2023.1198848

 received in 2023-04-03, accepted in 2023-05-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

The recent COVID-19 pandemic led to many drastic changes in not only society, law, economics, but also in science and medicine, marking for the first time when drug regulatory authorities cleared for use mRNA-based vaccines in the fight against this outbreak. However, while indeed representing a novel application of such technology in the context of vaccination medicine, introducing RNA into cells to produce resultant molecules (proteins, antibodies, etc.) is not a novel principle. It has been common practice to introduce/inject mRNA into oocytes and embryos to inhibit, induce, and identify several factors in a research context, while such aspects have also been proposed as potential therapeutic and diagnostic applications to combat infertility in humans. Herein, we describe key areas where mRNA-based platforms have thus far represented potential areas of clinical applications, describing the advantages and limitations of such applications. Finally, we also discuss how recent advances in mRNA-based platforms, driven by the recent pandemic, may stand to benefit the treatment of infertility in humans. We also present brief future directions as to how we could utilise recent and current advancements to enhance RNA therapeutics within reproductive biology, specifically with relation to oocyte and embryo delivery.

【 授权许可】

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Copyright © 2023 Bafleh, Abdulsamad, Al-Qaraghuli, El Khatib, Elbahrawi, Abdukadir, Alsawae, Dimassi, Hamdan and Kashir.