Using mixed reality technique combines multimodal imaging signatures to adjuvant glioma photodynamic therapy

Frontiers in Medicine

Medicine

Hang Ji¹  Shaoshan Hu¹  Xin Gao¹  Hongtao Zhao¹  Yuyun Xu²  Lihai Wang³  Zhaowen Qiu⁴  Zhihui Liu⁵  Fang Wang⁵  Jiawei Dong⁵  Jiheng Zhang⁵  Xiuwei Yan⁵  Jiaqi Jin⁵  Nan Wang⁵  Ruiqi Cheng⁶ 

[1] Cancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China;Cancer Center, Department of Radiology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China;College of Engineering and Technology, Northeast Forestry University, Harbin, China;College of Information and Computer Engineering, Northeast Forestry University, Harbin, China;Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;Cancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China;Heilongjiang Tuomeng Technology Co., Ltd, Harbin, China;

关键词: glioma;    photodynamic therapy;    magnetic resonance imaging;    mixed reality;    HoloLens;   

DOI  :  10.3389/fmed.2023.1171819

 received in 2023-02-22, accepted in 2023-06-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundPhotodynamic therapy (PDT) promotes significant tumor regression and extends the lifetime of patients. The actual operation of PDT often relies on the subjective judgment of experienced neurosurgeons. Patients can benefit more from precisely targeting PDT’s key operating zones.MethodsWe used magnetic resonance imaging scans and created 3D digital models of patient anatomy. Multiple images are aligned and merged in STL format. Neurosurgeons use HoloLens to import reconstructions and assist in PDT execution. Also, immunohistochemistry was used to explore the association of hyperperfusion sites in PDT of glioma with patient survival.ResultsWe constructed satisfactory 3D visualization of glioma models and accurately localized the hyperperfused areas of the tumor. Tumor tissue taken in these areas was rich in CD31, VEGFA and EGFR that were associated with poor prognosis in glioma patients. We report the first study using MR technology combined with PDT in the treatment of glioma. Based on this model, neurosurgeons can focus PDT on the hyperperfused area of the glioma. A direct benefit was expected for the patients in this treatment.ConclusionUsing the Mixed Reality technique combines multimodal imaging signatures to adjuvant glioma PDT can better exploit the vascular sealing effect of PDT on glioma.

【 授权许可】

Unknown   
Copyright © 2023 Dong, Wang, Xu, Gao, Zhao, Zhang, Wang, Liu, Yan, Jin, Ji, Cheng, Wang, Qiu and Hu.