The cell origins of foam cell and lipid metabolism regulated by mechanical stress in atherosclerosis

Frontiers in Physiology

Physiology

Jian Zhong¹  Zhi Ouyang¹  Junyi Shen¹  Ye Zeng² 

[1] Institute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China;null;

关键词: atherosclerosis;    foam cell;    lipid metabolism;    mechanical force;    endothelial cell;   

DOI  :  10.3389/fphys.2023.1179828

 received in 2023-03-07, accepted in 2023-04-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

Atherosclerosis is an inflammatory disease initiated by endothelial activation, in which lipoprotein, cholesterol, extracellular matrix, and various types of immune and non-immune cells are accumulated and formed into plaques on the arterial wall suffering from disturbed flow, characterized by low and oscillating shear stress. Foam cells are a major cellular component in atherosclerotic plaques, which play an indispensable role in the occurrence, development and rupture of atherosclerotic plaques. It was previously believed that foam cells were derived from macrophages or smooth muscle cells, but recent studies have suggested that there are other sources of foam cells. Many studies have found that the distribution of atherosclerotic plaques is not random but distributed at the bend and bifurcation of the arterial tree. The development and rupture of atherosclerotic plaque are affected by mechanical stress. In this review, we reviewed the advances in foam cell formation in atherosclerosis and the regulation of atherosclerotic plaque and lipid metabolism by mechanical forces. These findings provide new clues for investigating the mechanisms of atherosclerotic plaque formation and progression.

【 授权许可】

Unknown   
Copyright © 2023 Ouyang, Zhong, Shen and Zeng.