A nerve-wracking buzz: lessons from Drosophila models of peripheral neuropathy and axon degeneration

Frontiers in Aging Neuroscience

Neuroscience

Martha R. C. Bhattacharya¹ 

[1] null;

关键词: Drosophila;    peripheral neuropathy;    axon degeneration;    ALS;    Charcot-Marie Tooth disease;   

DOI  :  10.3389/fnagi.2023.1166146

 received in 2023-02-14, accepted in 2023-07-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

The degeneration of axons and their terminals occurs following traumatic, toxic, or genetically-induced insults. Common molecular mechanisms unite these disparate triggers to execute a conserved nerve degeneration cascade. In this review, we will discuss how models of peripheral nerve injury and neuropathy in Drosophila have led the way in advancing molecular understanding of axon degeneration and nerve injury pathways. Both neuron-intrinsic as well as glial responses to injury will be highlighted. Finally, we will offer perspective on what additional questions should be answered to advance these discoveries toward clinical interventions for patients with neuropathy.

【 授权许可】

Unknown   
Copyright © 2023 Bhattacharya.