Skin gluten-related disorders: new and old cutaneous manifestations to be considered

Frontiers in Medicine

Medicine

Marzia Caproni¹  Alice Verdelli¹  Lavinia Quintarelli¹  Veronica Bonciolini²  Alberto Corrà³  Elena Biancamaria Mariotti³  Cristina Aimo³  Emiliano Antiga³  Valentina Ruffo di Calabria³  Marta Elettra Donati³ 

[1] Department of Health Sciences, Rare Dermatological Diseases Unit, Azienda USL Toscana Centro, European Reference Network-Skin Member, Florence, Italy;Dermatology Unit, San Jacopo Hospital, Pistoia, Italy;Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy;

关键词: gluten-related disorders;    skin extra-intestinal manifestations;    coeliac disease;    dermatitis herpetiformis;    wheat allergy;    non-celiac gluten sensitivity;   

DOI  :  10.3389/fmed.2023.1155288

 received in 2023-01-31, accepted in 2023-04-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

The term gluten-related disorders (GRD) refer to a spectrum of different clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals, including coeliac disease (CD), wheat allergy and non-celiac gluten sensitivity (NCGS). GRD are characterized by a large variety of clinical presentations with both intestinal and extra-intestinal manifestations. The latter may affect almost every organ of the body, including the skin. Besides the well-known association between CD and dermatitis herpetiformis, considered as the cutaneous specific manifestation of CD, many other muco-cutaneous disorders have been associated to GRD. In this review, we analyzed the main features of dermatological diseases with a proven association with GRD and those that improve after a gluten-free diet, focusing on the newly described cutaneous manifestations associated with NCGS. Our main hypothesis is that a “cutaneous-gluten sensitivity,” as specific cutaneous manifestation of NCGS, may exist and could represent a diagnostic marker of NCGS.

【 授权许可】

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Copyright © 2023 Alice, Corrà, Mariotti, Aimo, Quintarelli, Ruffo di Calabria, Elettra Donati, Bonciolini, Antiga and Caproni.