The key role of microRNA-766 in the cancer development

Frontiers in Oncology

Oncology

Andrés Alexis Ramírez-Coronel¹  Fahad Alsaikhan²  Bagher Farhood³  Hussein Riyadh Abdul Kareem Al-Hetty⁴  Murtadha Sh. Aswood⁵  Zafar Aminov⁶  Pushpamala Ramaiah⁷  Jitendra Gupta⁸  Abduladheem Turki Jalil⁹  Maha Dhurgham Azeez^1,10 

[1] Azogues Campus Nursing Career, Health and Behavior Research Group (HBR), Psychometry and Ethology Laboratory, Catholic University of Cuenca, Cuenca, Ecuador;Epidemiology and Biostatistics Research Group, CES University, Medellín, Colombia;Educational Statistics Research Group (GIEE), National University of Education, Azogues, Ecuador;College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia;Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran;Department of Nursing, Al-Maarif University College, Ramadi, Anbar, Iraq;Department of Physics, College of Education, University of Al-Qadisiyah, Al-Diwaniyah, Iraq;Department of Public Health and Healthcare management, Samarkand State Medical University, Samarkand, Uzbekistan;Department of Scientific Affairs, Tashkent State Dental Institute, Tashkent, Uzbekistan;Faculty of Nursing, Umm al-Qura University, Makkah, Saudi Arabia;Institute of Pharmaceutical Research, GLA University, Mathura, India;Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla, Iraq;National University of Science and Technology, Dhi Qar, Iraq;

关键词: cancer;    microRNA;    miR-766;    biomarker;    drug resistance;   

DOI  :  10.3389/fonc.2023.1173827

 received in 2023-02-25, accepted in 2023-04-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cancer is caused by defects in coding and non-coding RNAs. In addition, duplicated biological pathways diminish the efficacy of mono target cancer drugs. MicroRNAs (miRNAs) are short, endogenous, non-coding RNAs that regulate many target genes and play a crucial role in physiological processes such as cell division, differentiation, cell cycle, proliferation, and apoptosis, which are frequently disrupted in diseases such as cancer. MiR-766, one of the most adaptable and highly conserved microRNAs, is notably overexpressed in several diseases, including malignant tumors. Variations in miR-766 expression are linked to various pathological and physiological processes. Additionally, miR-766 promotes therapeutic resistance pathways in various types of tumors. Here, we present and discuss evidence implicating miR-766 in the development of cancer and treatment resistance. In addition, we discuss the potential applications of miR-766 as a therapeutic cancer target, diagnostic biomarker, and prognostic indicator. This may shed light on the development of novel therapeutic strategies for cancer therapy.

【 授权许可】

Unknown   
Copyright © 2023 Gupta, Kareem Al-Hetty, Aswood, Turki Jalil, Azeez, Aminov, Alsaikhan, Ramírez-Coronel, Ramaiah and Farhood