Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Walid Kamal Abdelbasset¹  Ria Margiana²  Mostafa Jarahian³  Dmitry O. Bokov⁴  Rajender S. Varma⁵  Nasrin Beheshtkhoo⁶  Mohammad Amin Jadidi Kouhbanani⁶  Faroogh Marofi⁷  Pooria Nakhaei⁸ 

[1] Al Kharj, Saudi Arabia;Giza, Egypt;Depok, Indonesia;Central Jakarta, Indonesia;Depok, Indonesia;Heidelberg, Germany;Moscow, Russia;Moscow, Russia;Olomouc, Czechia;Shiraz, Czechia;Tabriz, Iran;Tehran, Iran;

关键词: liposome;    lipids;    compounds;    cholesterol;    stability;   

DOI  :  10.3389/fbioe.2021.705886

 received in 2021-05-06, accepted in 2021-08-09,  发布年份 2021

来源: Frontiers

【 摘 要 】

Liposomes are essentially a subtype of nanoparticles comprising a hydrophobic tail and a hydrophilic head constituting a phospholipid membrane. The spherical or multilayered spherical structures of liposomes are highly rich in lipid contents with numerous criteria for their classification, including structural features, structural parameters, and size, synthesis methods, preparation, and drug loading. Despite various liposomal applications, such as drug, vaccine/gene delivery, biosensors fabrication, diagnosis, and food products applications, their use encounters many limitations due to physico-chemical instability as their stability is vigorously affected by the constituting ingredients wherein cholesterol performs a vital role in the stability of the liposomal membrane. It has well established that cholesterol exerts its impact by controlling fluidity, permeability, membrane strength, elasticity and stiffness, transition temperature (Tm), drug retention, phospholipid packing, and plasma stability. Although the undetermined optimum amount of cholesterol for preparing a stable and controlled release vehicle has been the downside, but researchers are still focused on cholesterol as a promising material for the stability of liposomes necessitating explanation for the stability promotion of liposomes. Herein, the prior art pertaining to the liposomal appliances, especially for drug delivery in cancer therapy, and their stability emphasizing the roles of cholesterol.

【 授权许可】

Unknown   
Copyright © 2021 Nakhaei, Margiana, Bokov, Abdelbasset, Jadidi Kouhbanani, Varma, Marofi, Jarahian and Beheshtkhoo.