Ultrasonic neuromodulation mediated by mechanosensitive ion channels: current and future

Frontiers in Neuroscience

Neuroscience

Sixuan He¹  Huijing Hu¹  Le Li¹  Mingxia Zhang¹  Mengyao Song¹ 

[1] Institute of Medical Research, Northwestern Polytechnical University, Xi’an, China;Research and Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China;

关键词: ultrasound;    neuromodulation;    Piezo ion channels;    transient receptor potential channels;    mechanosensitive ion channels;   

DOI  :  10.3389/fnins.2023.1232308

 received in 2023-05-31, accepted in 2023-07-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

Ultrasound neuromodulation technology is a promising neuromodulation approach, with the advantages of noninvasiveness, high-resolution, deep penetration and good targeting, which aid in circumventing the side effects of drugs and invasive therapeutic interventions. Ultrasound can cause mechanical effects, activate mechanosensitive ion channels and alter neuronal excitability, producing biological effects. The structural determination of mechanosensitive ion channels will greatly contribute to our understanding of the molecular mechanisms underlying mechanosensory transduction. However, the underlying biological mechanism of ultrasonic neuromodulation remains poorly understood. Hence, this review aims to provide an outline of the properties of ultrasound, the structures of specific mechanosensitive ion channels, and their role in ultrasound neuromodulation.

【 授权许可】

Unknown   
Copyright © 2023 Song, Zhang, He, Li and Hu.