Mechanisms and Applications of Neuromodulation Using Surface Acoustic Waves—A Mini-Review

Frontiers in Neuroscience

David J. Collins¹  Michael R. Ibbotson²  Wei Tong²  Steven Prawer⁴  Melanie Stamp⁴  Danli Peng⁴ 

[1] Biomedical Engineering Department, The University of Melbourne, Melbourne, VIC, Australia;Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, VIC, Australia;National Vision Research Institute, Australian College of Optometry, Carlton, VIC, Australia;School of Physics, The University of Melbourne, Melbourne, VIC, Australia;

关键词: surface acoustic wave;    neuron;    neurostimulation;    neuromodulation;    ultrasound;    mechanisms;   

DOI  :  10.3389/fnins.2021.629056

来源: DOAJ

【 摘 要 】

The study of neurons is fundamental for basic neuroscience research and treatment of neurological disorders. In recent years ultrasound has been increasingly recognized as a viable method to stimulate neurons. However, traditional ultrasound transducers are limited in the scope of their application by self-heating effects, limited frequency range and cavitation effects during neuromodulation. In contrast, surface acoustic wave (SAW) devices, which are producing wavemodes with increasing application in biomedical devices, generate less self-heating, are smaller and create less cavitation. SAW devices thus have the potential to address some of the drawbacks of traditional ultrasound transducers and could be implemented as miniaturized wearable or implantable devices. In this mini review, we discuss the potential mechanisms of SAW-based neuromodulation, including mechanical displacement, electromagnetic fields, thermal effects, and acoustic streaming. We also review the application of SAW actuation for neuronal stimulation, including growth and neuromodulation. Finally, we propose future directions for SAW-based neuromodulation.

【 授权许可】

Unknown