Two tripartite classification systems of CD86+ and CD206+ macrophages are significantly associated with tumor recurrence in stage II-III colorectal cancer

Frontiers in Immunology

Immunology

Jian Chen¹  Qingqing Wei²  Jing Li²  Yuzhen Mo³  Fuxiang Zhou⁴  Guozeng Xu⁵ 

[1] Department of Medical Oncology, Yantai Yuhuangding Hospital of Qingdao University, Shandong, China;Department of Oncology, Liuzhou People’s Hospital of Guangxi Medical University, Guangxi, China;Department of Radiation Oncology, Guangzhou Red Cross Hospital of Jinan University, Guangdong, China;Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei, China;Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei, China;Department of Oncology, Liuzhou People’s Hospital of Guangxi Medical University, Guangxi, China;

关键词: CD86;    CD206;    colorectal cancer;    macrophage polarization;    tripartite classification system;   

DOI  :  10.3389/fimmu.2023.1136875

 received in 2023-01-03, accepted in 2023-05-22,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionThe prognostic value of tumor-associated macrophages remains unclear in colorectal cancer (CRC). Two tripartite classification systems, namely, ratio and quantity subgroups, were investigated as the prognostic stratification tools for stage II-III CRC. MethodsWe assessed the infiltration intensity of CD86+ and CD206+ macrophages in 449 cases with stage II-III disease by immunohistochemical staining. Ratio subgroups were defined by the lower- and upper-quartile points of CD206+/(CD86++CD206+) macrophage ratio, including the low-, moderate-, and high-ratio subgroups. Quantity subgroups were defined by the median points of CD86+ and CD206+ macrophages and included the low-, moderate-, and high-risk subgroups. The main analysis was recurrence-free survival (RFS) and overall survival (OS). ResultsRatio subgroups (RFS/OS: HR=2.677/2.708, all p<0.001) and quantity subgroups (RFS/OS: HR=3.137/3.250, all p<0.001) could serve as independent prognostic indicators that effectively predicted survival outcomes. More importantly, log-rank test revealed that patients in the high-ratio (RFS/OS: HR=2.950/3.151, all p<0.001) or high-risk (RFS/OS: HR=3.453/3.711, all p<0.001) subgroup exhibited decreased survival outcomes after adjuvant chemotherapy. The predictive accuracy of the quantity subgroups within 48 months was higher than that of the ratio subgroups and tumor stage (all p<0.05).ConclusionsRatio and quantity subgroups could serve as independent prognostic indicators that could potentially be incorporated into the tumor staging algorithm to improve prognostic stratification and provide better predictions of survival outcomes in stage II-III CRC after adjuvant chemotherapy.

【 授权许可】

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Copyright © 2023 Xu, Mo, Li, Wei, Zhou and Chen